Comment on

• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

  Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G. Noguera-Troise I, et al. Nature. 2006 Dec 21;444(7122):1032-7. doi: 10.1038/nature05355. Nature. 2006. PMID: 17183313
• Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis.

  Ridgway J, Zhang G, Wu Y, Stawicki S, Liang WC, Chanthery Y, Kowalski J, Watts RJ, Callahan C, Kasman I, Singh M, Chien M, Tan C, Hongo JA, de Sauvage F, Plowman G, Yan M. Ridgway J, et al. Nature. 2006 Dec 21;444(7122):1083-7. doi: 10.1038/nature05313. Nature. 2006. PMID: 17183323
• Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries.

  Siekmann AF, Lawson ND. Siekmann AF, et al. Nature. 2007 Feb 15;445(7129):781-4. doi: 10.1038/nature05577. Epub 2007 Jan 28. Nature. 2007. PMID: 17259972
• Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.

  Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalén M, Gerhardt H, Betsholtz C. Hellström M, et al. Nature. 2007 Feb 15;445(7129):776-80. doi: 10.1038/nature05571. Epub 2007 Jan 28. Nature. 2007. PMID: 17259973