Comment
doi: 10.1016/j.cmet.2007.01.010.
The metabolic sensor GCN2 branches out
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- PMID: 17276350
- DOI: 10.1016/j.cmet.2007.01.010
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Comment
The metabolic sensor GCN2 branches out
Cell Metab.
2007 Feb.
Free article
Abstract
GCN2 is a sensor of amino acid deprivation that triggers a repression of global protein synthesis while simultaneously inducing translation of specific proteins. In this issue of Cell Metabolism, Guo and Cavener (2007) present a much broader role for GCN2 in controlling lipid homeostasis in response to amino acid deprivation.
Comment on
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The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid.Cell Metab. 2007 Feb;5(2):103-14. doi: 10.1016/j.cmet.2007.01.001. Cell Metab. 2007. PMID: 17276353
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