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Review
. 2006 Dec;25(6):862-4.
doi: 10.1016/j.immuni.2006.11.005.

Maintaining hematopoietic stem cells in the vascular niche

Mark J Kiel  1 , Sean J Morrison
Affiliations
Free article
Review

Maintaining hematopoietic stem cells in the vascular niche

Mark J Kiel et al. Immunity. 2006 Dec.
Free article

Abstract

In this issue of Immunity, Sugiyama et al. (2006) provide evidence that most bone-marrow hematopoietic stem cells (HSCs) reside in vascular niches containing reticular cells that secrete CXCL12, a chemokine that promotes HSC maintenance.

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