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Comparative Study
. 1991 May 23;351(6324):290-6.
doi: 10.1038/351290a0.

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

K Falk  1 , O Rötzschke, S Stevanović, G Jung, H G Rammensee
Affiliations
Comparative Study

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

K Falk et al. Nature. .

Abstract

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere.

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