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Comparative Study
. 2006 Nov 9;52(3):437-44.
doi: 10.1016/j.neuron.2006.08.024.

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories

Niels Plath  1 , Ora Ohana, Björn Dammermann, Mick L Errington, Dietmar Schmitz, Christina Gross, Xiaosong Mao, Arne Engelsberg, Claudia Mahlke, Hans Welzl, Ursula Kobalz, Anastasia Stawrakakis, Esperanza Fernandez, Robert Waltereit, Anika Bick-Sander, Eric Therstappen, Sam F Cooke, Veronique Blanquet, Wolfgang Wurst, Benedikt Salmen, Michael R Bösl, Hans-Peter Lipp, Seth G N Grant, Tim V P Bliss, David P Wolfer, Dietmar Kuhl
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Free article
Comparative Study

Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories

Niels Plath et al. Neuron. .
Free article

Abstract

Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.

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