Review
doi: 10.1016/j.cmet.2006.10.009.
Banking on ATM as a new target in metabolic syndrome
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- PMID: 17084707
- DOI: 10.1016/j.cmet.2006.10.009
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Review
Banking on ATM as a new target in metabolic syndrome
Cell Metab.
2006 Nov.
Free article
Abstract
In this issue of Cell Metabolism, Semenkovich and his colleagues show that ATM, a protein well known for its roles in the cellular response to DNA breaks, may also be linked to metabolic and cardiovascular diseases (Schneider et al., 2006). ATM seemingly does this by inhibiting JNK, a stress kinase involved in inflammation with related effects in insulin resistance and atherosclerosis. In an interesting twist, the authors show that chloroquine, an antimalarial drug, also activates ATM, which inhibits JNK, and improves insulin sensitivity and cardiovascular effects. These findings provide potential new insights into the pathogenesis and treatment of metabolic syndrome.
Comment on
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ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome.Cell Metab. 2006 Nov;4(5):377-89. doi: 10.1016/j.cmet.2006.10.002. Cell Metab. 2006. PMID: 17084711
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