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Review
. 2006 Apr;18(2):164-74.
doi: 10.1016/j.coi.2006.01.008. Epub 2006 Feb 7.

AID in somatic hypermutation and class switch recombination

Simonne Longerich  1 , Uttiya Basu, Frederick Alt, Ursula Storb
Affiliations
Review

AID in somatic hypermutation and class switch recombination

Simonne Longerich et al. Curr Opin Immunol. 2006 Apr.

Abstract

Somatic hypermutation and class-switch-recombination are initiated by the deamination of deoxycytosine in DNA by activation-induced-deaminase, AID. Recently, there has been much research into how AID targets double-stranded DNA in sub-regions of Ig genes, the involvement of co-factors and posttranslational modifications in this process, the co-option of DNA 'repair' mechanisms and AID evolution.

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