Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2006 Feb;84(1):66-71.
doi: 10.1111/j.1440-1711.2005.01409.x.

Addressing the mysteries of perforin function

Ilia Voskoboinik  1 , Joseph A Trapani
Affiliations
Review

Addressing the mysteries of perforin function

Ilia Voskoboinik et al. Immunol Cell Biol. 2006 Feb.

Abstract

Perforin is a cytolytic protein stored in secretory granules of CTL and NK cells. It synergizes with proapoptotic serine proteases, granzymes, to deliver the lethal hit to virus-infected or transformed target cells. The mechanism of perforin action has not been described beyond its original characterization in the 1980s, and its role in human disease has remained elusive. This article addresses recent key advances in genetic, clinical and biochemical studies that have reignited the current interest in perforin biology.

PubMed Disclaimer

Publication types

LinkOut - more resources