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Review
. 2005 Sep;185(3):763-7.
doi: 10.2214/ajr.185.3.01850763.

The role of blood-brain barrier permeability in brain tumor imaging and therapeutics

James M Provenzale  1 , Srinivasan Mukundan, Mark Dewhirst
Affiliations
Review

The role of blood-brain barrier permeability in brain tumor imaging and therapeutics

James M Provenzale et al. AJR Am J Roentgenol. 2005 Sep.

Abstract

Objective: Our purpose is to describe methods of assessing leakiness of the blood-brain barrier and explain mechanisms for exploiting the blood-brain barrier for therapeutic purposes.

Conclusion: Knowledge of the workings of the blood-brain barrier is important for an understanding of the ways in which blood-brain barrier permeability may be used as a surrogate marker for drug therapeutic response. Manipulation of the blood-brain barrier may provide a means for selectively targeting tumors for drug delivery.

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