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. 2005 Apr 15;308(5720):381-5.
doi: 10.1126/science.1107573.

An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head

Kimberly A Mace  1 , Joseph C Pearson, William McGinnis
Affiliations

An epidermal barrier wound repair pathway in Drosophila is mediated by grainy head

Kimberly A Mace et al. Science. .

Abstract

We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier.

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