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. 2005 Mar 21;29(6):270-4.
doi: 10.1016/j.cyto.2004.10.017.

Adipose tissue is a regulated source of interleukin-10

Cristiana E Juge-Aubry  1 , Emmanuel Somm, Agnès Pernin, Navid Alizadeh, Vittorio Giusti, Jean-Michel Dayer, Christoph A Meier
Affiliations

Adipose tissue is a regulated source of interleukin-10

Cristiana E Juge-Aubry et al. Cytokine. .

Abstract

White adipose tissue (WAT) is the source of pro- and anti-inflammatory cytokines and we have recently shown that this tissue is a major source of the anti-inflammatory interleukin (IL)-1 receptor antagonist (IL-1Ra). We now aimed at identifying additional adipose-derived cytokines, which might serve as regulators of IL-1Ra. We demonstrate here for the first time that the antiinflammatory cytokine IL-10 is secreted by human WAT explants and that it is up-regulated by LPS and TNF-alpha in vitro, as well as in obesity in humans (2- and 6-fold increase in subcutaneous and visceral WAT, respectively) and rodents (4-fold increase).

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