Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Sep 1;64(17):5943-7.
doi: 10.1158/0008-5472.CAN-04-1606.

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth

Lorenzo Romero-Ramirez  1 , Hongbin Cao, Daniel Nelson, Ester Hammond, Ann-Hwee Lee, Hiderou Yoshida, Kazutoshi Mori, Laurie H Glimcher, Nicholas C Denko, Amato J Giaccia, Quynh-Thu Le, Albert C Koong
Affiliations

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth

Lorenzo Romero-Ramirez et al. Cancer Res. .

Abstract

Hypoxia within solid tumors is a major determinant of outcome after anticancer therapy. Analysis of gene expression changes during hypoxia indicated that unfolded protein response genes were one of the most robustly induced groups of genes. In this study, we investigated the hypoxic regulation of X-box binding protein (XBP1), a major transcriptional regulator of the unfolded protein response. Hypoxia induced XBP1 at the transcriptional level and activated splicing of its mRNA, resulting in increased levels of activated XBP1 protein. After exposure to hypoxia, apoptosis increased and clonogenic survival decreased in XBP1-deficient cells. Loss of XBP1 severely inhibited tumor growth due to a reduced capacity for these transplanted tumor cells to survive in a hypoxic microenvironment. Taken together, these studies directly implicate XBP1 as an essential survival factor for hypoxic stress and tumor growth.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources