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. 2004 Jul;27(4):225-34.
doi: 10.1016/S0147-9571(03)00011-0.

Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers

R Gupta  1 , I Verma, S Sharma, N K Ganguly
Affiliations

Prevention of tissue injury in an ascending mouse model of chronic pyelonephritis--role of free radical scavengers

R Gupta et al. Comp Immunol Microbiol Infect Dis. 2004 Jul.

Abstract

The role of free radical scavengers in preventing the tissue injury using a non obstructive, ascending mouse model for chronic pyelonephritis was assessed. The parameters taken into consideration are Luminol Dependent Chemiluminescence (LDCL), histopathology and some biochemical investigations. We have observed that both catalase and Dimethyl-Sulfoxide (DMSO, free radical scavengers) were able to prevent the free radical mediated tissue injury and ultimate renal scarring, irrespective of the bacterial strain studied.

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