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Review
. 2004 Apr;131(8):1663-77.
doi: 10.1242/dev.01117.

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way

Xi He  1 , Mikhail Semenov, Keiko Tamai, Xin Zeng
Affiliations
Review

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way

Xi He et al. Development. 2004 Apr.

Abstract

Wnt signaling through the canonical beta-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/beta-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular beta-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.

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