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. 1992 Nov 19;360(6401):232-9.
doi: 10.1038/360232a0.

Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2

E Y Jones  1 , S J Davis, A F Williams, K Harlos, D I Stuart
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Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2

E Y Jones et al. Nature. .

Abstract

The crystal structure of a soluble form of the T lymphocyte antigen CD2 provides the first complete view of the extracellular region of a cell adhesion molecule. The topology of the molecule, which comprises two immunoglobulin-like domains, is the same as that of the first two domains of CD4 but the relative domain orientation is altered by a fairly flexible linker region. The putative ligand-binding beta-sheet forms a flat surface towards the top of the molecule. Crystal contacts between these surfaces suggest a plausible model for the adhesive interaction.

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