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. 2003 Jun;4(6):879-89.
doi: 10.1016/s1534-5807(03)00161-8.

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

Rainer Zenz  1 , Harald Scheuch, Paul Martin, Carsten Frank, Robert Eferl, Lukas Kenner, Maria Sibilia, Erwin F Wagner
Affiliations
Free article

c-Jun regulates eyelid closure and skin tumor development through EGFR signaling

Rainer Zenz et al. Dev Cell. 2003 Jun.
Free article

Abstract

To investigate the function of c-Jun during skin development and skin tumor formation, we conditionally inactivated c-jun in the epidermis. Mice lacking c-jun in keratinocytes (c-jun(Deltaep)) develop normal skin but express reduced levels of EGFR in the eyelids, leading to open eyes at birth, as observed in EGFR null mice. Primary keratinocytes from c-jun(Deltaep) mice proliferate poorly, show increased differentiation, and form prominent cortical actin bundles, most likely because of decreased expression of EGFR and its ligand HB-EGF. In the absence of c-Jun, tumor-prone K5-SOS-F transgenic mice develop smaller papillomas, with reduced expression of EGFR in basal keratinocytes. Thus, using three experimental systems, we show that EGFR and HB-EGF are regulated by c-Jun, which controls eyelid development, keratinocyte proliferation, and skin tumor formation.

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