Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2003 Apr;74(2):173-9.
doi: 10.1016/s0014-4800(03)00005-4.

Microtubules are required for cytokeratin aggresome (Mallory body) formation in hepatocytes: an in vitro study

N E Riley  1 , F Bardag-Gorce, R O Montgomery, J Li, W Lungo, Y H Lue, S W French
Affiliations
Comparative Study

Microtubules are required for cytokeratin aggresome (Mallory body) formation in hepatocytes: an in vitro study

N E Riley et al. Exp Mol Pathol. 2003 Apr.

Abstract

Mallory bodies are cytokeratin-ubiquitin aggresomes that form in hepatocytes in many different chronic liver diseases. One of the key components in aggresome formation, not yet investigated in Mallory body formation, is the role of microtubules. An in vitro tissue culture assay is required to test for microtubule involvement in Mallory body formation so that Mallory body formation can be observed in the presence or absence of microtubule-disrupting agents. In this report, a new model of in vitro Mallory body formation was developed, which uses cultured hepatocytes isolated from drug-primed mice. When hepatocytes were incubated in the presence of antimicrotubule agents, they failed to form Mallory bodies. It is concluded that intact microtubules are required for Mallory body formation.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources