Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Mar;120(5):850-2.
doi: 10.1046/j.1365-2141.2003.04147.x.

Involvement of cytotoxic granules in the apoptosis of aplastic anaemia

J L Xu  1 , T Nagasaka, N Nakashima
Affiliations

Involvement of cytotoxic granules in the apoptosis of aplastic anaemia

J L Xu et al. Br J Haematol. 2003 Mar.

Abstract

To study the involvement of cytotoxic granules in apoptosis of aplastic anaemia (AA), we analysed bone marrow clot sections of AA for apoptosis and perforin, granzyme B and T-cell intracellular antigen-1 (TIA-1) expression. Perforin, TIA-1 expression and apoptosis were significantly increased in AA patients compared with control subjects, but granzyme B was not. TIA-1 was significantly correlated with apoptotic cells of AA. No correlation was found between perforin and apoptotic cells of AA. These results suggest that perforin and TIA-1 play a role in the pathogenesis of AA. TIA-1 is implicated as an effector in the apoptosis of AA.

PubMed Disclaimer

MeSH terms

LinkOut - more resources