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. 2002 Dec 13;298(5601):2188-90.
doi: 10.1126/science.1077857.

Heart regeneration in zebrafish

Kenneth D Poss  1 , Lindsay G Wilson, Mark T Keating
Affiliations

Heart regeneration in zebrafish

Kenneth D Poss et al. Science. .

Abstract

Cardiac injury in mammals and amphibians typically leads to scarring, with minimal regeneration of heart muscle. Here, we demonstrate histologically that zebrafish fully regenerate hearts within 2 months of 20% ventricular resection. Regeneration occurs through robust proliferation of cardiomyocytes localized at the leading epicardial edge of the new myocardium. The hearts of zebrafish with mutations in the Mps1 mitotic checkpoint kinase, a critical cell cycle regulator, failed to regenerate and formed scars. Thus, injury-induced cardiomyocyte proliferation in zebrafish can overcome scar formation, allowing cardiac muscle regeneration. These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration.

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Comment in

  • Development. Fishing out a new heart.
    Scott IC, Stainier DY. Scott IC, et al. Science. 2002 Dec 13;298(5601):2141-2. doi: 10.1126/science.1079821. Science. 2002. PMID: 12481123 No abstract available.

MeSH terms