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. 2002 Nov 1;169(9):4882-8.
doi: 10.4049/jimmunol.169.9.4882.

4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1

Hyeon-Woo Lee  1 , Su-Jung Park, Beom K Choi, Hyun Hwa Kim, Kyung-Ok Nam, Byoung S Kwon
Affiliations

4-1BB promotes the survival of CD8+ T lymphocytes by increasing expression of Bcl-xL and Bfl-1

Hyeon-Woo Lee et al. J Immunol. .

Abstract

4-1BB, a T cell costimulatory receptor, prolongs CD8(+) T cell survival. In these studies, 4-1BB stimulation was shown to increase expression of the antiapoptotic genes bcl-x(L) and bfl-1 via 4-1BB-mediated NF-kappaB activation. This signaling pathway was specifically inhibited by PDTC and was different from the pathways that enhanced CD8(+) T cell proliferation. The results suggest a role for the antiapoptotic activities of Bcl-x(L) and Bfl-1 proteins in 4-1BB-mediated CD8(+) T cell survival in vivo.

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