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. 2002 Oct;8(5):822-6.
doi: 10.3748/wjg.v8.i5.822.

Expression of p53 and C-myc genes and its clinical relevance in the hepatocellular carcinomatous and pericarcinomatous tissues

Zhao-Shan Niu  1 , Bo-Kian Li, Mei Wang
Affiliations

Expression of p53 and C-myc genes and its clinical relevance in the hepatocellular carcinomatous and pericarcinomatous tissues

Zhao-Shan Niu et al. World J Gastroenterol. 2002 Oct.

Abstract

Aim: To investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule (LHN) and hepatocellular carcinoma(HCC).

Methods: The expression of p53 and C-myc genes was detected immunohistochemically in 73 and 60 cases of HCC and pericarcinomatous tissues, respectively.

Results: The positive expression of p53 in HCC was significantly higher than that in pericarcinomatous tissues (P<0.05). In pericarcinomatous tissues, the p53 expression was observed only in LHN, but not in liver cirrhosis (LC) and normal liver tissues. The positive expression rate of C-myc in HCC or LHN was significantly higher than that in LC or normal liver tissues (P<0.05 and P<0.01), however, no significant difference was found between HCC and LHN (P>0.05). The positive expression rate of p53 and C-myc in HCC was correlated with the histological differentiation, that in the poorly differentiated was significantly higher than that in well differentiated samples (P<0.05).

Conclusion: The overexpression of p53 and C-myc genes might play a role in the carcinogenesis of HCC; And LHN seems a preneoplastic lesion related to hepatocarcinogenesis; No evidence supports that LC contribute directly to the hepatocarcinogenesis.

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Figures

Figure 1
Figure 1
The positive expression of p53 gene in HCC. LSAB × 200
Figure 2
Figure 2
The positive expression of p53 gene in LHN. LSAB × 200
Figure 3
Figure 3
The positive expression of C-myc gene in HCC. LSAB × 200
Figure 4
Figure 4
The positive expression of C-myc gene in LHN. LSAB × 200
Figure 5
Figure 5
The positive expression of C-myc gene in LC. LSAB × 200
See this image and copyright information in PMC

References

    1. Sithinamsuwan P, Piratvisuth T, Tanomkiat W, Apakupakul N, Tongyoo S. Review of 336 patients with hepatocellular carcinoma at Songklanagarind Hospital. World J Gastroenterol. 2000;6:339–343. - PMC - PubMed
    1. Sun BH, Zhang J, Wang BJ, Zhao XP, Wang YK, Yu ZQ, Yang DL, Hao LJ. Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21 (WAF1) expression and hepatic apoptosis. World J Gastroenterol. 2000;6:356–360. - PMC - PubMed
    1. Xu HY, Yang YL, Guan XL, Song G, Jiang AM, Shi LJ. Expression of regulating apoptosis gene and apoptosis index in primary liver cancer. World J Gastroenterol. 2000;6:721–724. - PMC - PubMed
    1. Feng DY, Zheng H, Tan Y, Cheng RX. Effect of phosphorylation of MAPK and Stat3 and expression of c-fos and c-jun proteins on hepatocarcinogenesis and their clinical significance. World J Gastroenterol. 2001;7:33–36. - PMC - PubMed
    1. Cui J, Yang DH, Bi XJ, Fan ZR. Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology. World J Gastroenterol. 2001;7:136–139. - PMC - PubMed

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