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. 2001 Dec 28;107(7):893-903.
doi: 10.1016/s0092-8674(01)00612-2.

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

X Shen  1 , R E Ellis, K Lee, C Y Liu, K Yang, A Solomon, H Yoshida, R Morimoto, D M Kurnit, K Mori, R J Kaufman
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Free article

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

X Shen et al. Cell. .
Free article

Abstract

The unfolded protein response (UPR) is a transcriptional and translational intracellular signaling pathway activated by the accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). We have used C. elegans as a genetic model system to dissect UPR signaling in a multicellular organism. C. elegans requires ire-1-mediated splicing of xbp-1 mRNA for UPR gene transcription and survival upon ER stress. In addition, ire-1/xbp-1 acts with pek-1, a protein kinase that mediates translation attenuation, in complementary pathways that are essential for worm development and survival. We propose that UPR transcriptional activation by ire-1 as well as translational attenuation by pek-1 maintain ER homeostasis. The results demonstrate that the UPR and ER homeostasis are essential for metazoan development.

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