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. 2001 Dec;7(12):578-81.
doi: 10.1016/s1471-4914(01)02167-0.

Animal models for respiratory chain disease

N G Larsson  1 , P Rustin
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Animal models for respiratory chain disease

N G Larsson et al. Trends Mol Med. 2001 Dec.

Abstract

Elucidation of the pathogenesis in respiratory chain diseases is of great importance for developing specific treatments. The limitations inherent to the use of patient material make studies of human tissues often difficult and the mouse has therefore emerged as a suitable model organism for studies of respiratory chain diseases. In this review, we present an overview of the field and discuss in depth a few examples of animal models reproducing pathology of human disease with primary and secondary respiratory chain involvement.

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