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Review
. 2001 Oct 1;1551(2):F1-37.
doi: 10.1016/s0304-419x(01)00031-2.

Apoptosis regulators and their role in tumorigenesis

M Zörnig  1 , A Hueber, W Baum, G Evan
Affiliations
Review

Apoptosis regulators and their role in tumorigenesis

M Zörnig et al. Biochim Biophys Acta. .

Abstract

It has become clear that, together with deregulated growth, inhibition of programmed cell death (PCD) plays a pivotal role in tumorigenesis. In this review, we present an overview of the genes and mechanisms involved in PCD. We then summarize the evidence that impaired PCD is a prerequisite for tumorigenesis, as indicated by the fact that more and more neoplastic mutations appear to act by interfering with PCD. This has made the idea of restoration of corrupted 'death programs' an intriguing new area for potential cancer therapy.

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