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Review
. 1999 Nov 25;253(1):239-54.
doi: 10.1006/excr.1999.4701.

Signaling by distinct classes of phosphoinositide 3-kinases

B Vanhaesebroeck  1 , M D Waterfield
Affiliations
Review

Signaling by distinct classes of phosphoinositide 3-kinases

B Vanhaesebroeck et al. Exp Cell Res. .

Abstract

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affecting their localization, conformation, and activities. Here we review the activation mechanisms of the different types of PI3Ks and their downstream actions, with focus on the PI3Ks that are acutely triggered by extracellular stimulation.

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