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. 1999 Jul;43(7):1788-91.
doi: 10.1128/AAC.43.7.1788.

In vitro and in vivo activities of tea catechins against Helicobacter pylori

K Mabe  1 , M Yamada, I Oguni, T Takahashi
Affiliations

In vitro and in vivo activities of tea catechins against Helicobacter pylori

K Mabe et al. Antimicrob Agents Chemother. 1999 Jul.

Abstract

The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 microg/ml). It had bactericidal activity at pH 7 but not at pH </=5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.

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Figures

FIG. 1
FIG. 1
Chemical structures of tea catechins.
FIG. 2
FIG. 2
Effect of EGCg on H. pylori viability in liquid medium. H. pylori YMA78 was cultured microaerobically in Mueller-Hinton broth supplemented with 10% heat-inactivated horse serum at 37°C with reciprocation in the presence of EGCg at concentrations of 128 (▵), 64 (●), 32 (▴), 8 (■), and 0 (○) μg/ml. Culture samples (100 μl) were taken at the times indicated, and viability was measured by the plate colony count technique.
FIG. 3
FIG. 3
Effect of EGCg on H. pylori viability in buffers at various pHs. H. pylori YMA78 was incubated microaerobically in each buffer at 37°C with reciprocation in the presence of EGCg at concentrations of 500 (▴), 250 (●), and 0 (○) μg/ml. Viability was determined at each time point indicated.
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