Molecularly targeted therapy

Latest research

1. On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

   • Filippo Birocchi
   • Antonio J. Almazan
   • Marcela V. Maus

   in Nature Communications

   Article Open access 01 November 2025

   

2. Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies

   • Elizabeth J. Carstens
   • Kazuki Takahashi
   • Eric L. Smith

   in Nature Communications

   Article Open access 01 November 2025

   

3. Who Truly Benefits From First-Line Intensification in EGFR-Mutant NSCLC?

   • Michele Maffezzoli
   • Jason Lau
   • Giuseppe Luigi Banna

   in Current Oncology Reports

   Article Open access 01 November 2025

   

4. Induced proximity-based therapeutic modalities

   • Elizabeth A. King
   • Margot Meyers
   • Daniel K. Nomura

   in Nature Reviews Drug Discovery

   Article 31 October 2025

   

5. Real-world efficacy of postoperative adjuvant EGFR-TKI therapy for stage IA2-IA3 lung adenocarcinoma with high-risk pathological factors

   • Sida Lu
   • Chenxu Liu
   • Yi Shen

   in World Journal of Surgical Oncology

   Article Open access 31 October 2025

   

6. Targeting KRAS^G13C with cyclic linker based inhibitors to explore warhead orientation

   • Tonia Kirschner
   • João Rodriguez
   • Daniel Rauh

   in Scientific Reports

   Article Open access 31 October 2025

   

7. Pan-cancer Myc modulator that targets Myc-α-tubulin interaction to drive selective mitotic catastrophe

   • Jessica Teitel
   • Margaret Farah
   • Analisa DiFeo

   in Scientific Reports

   Article Open access 31 October 2025

   

8. Development of antibody drug conjugates targeting epithelial membrane protein 2-highly expressed lung cancer

   • Mengge Zheng
   • Su Hang
   • Haipeng Liu

   in Cell Death & Disease

   Article Open access 31 October 2025

   

9. Breaking barriers: the emerging promise of CAR-T cell therapy in solid tumors

   • Yongzhan Nie

   in Holistic Integrative Oncology

   Article Open access 31 October 2025

10. Advancing Medulloblastoma Treatment: Molecular Mechanisms, Drug Repurposing, and Precision Therapies

    • Mohammed A. Abdel-Rasol
    • Wael M. El-Sayed

    in Molecular Diagnosis & Therapy

    Article Open access 31 October 2025

    

11. WT1 gene: a potential therapeutic target for multiple cancer treatment strategies

    • Tetsuyuki Hirahata
    • Reeshan Ul Quraish
    • Reezan Ul Quraish

    in Clinical and Experimental Medicine

    Article Open access 31 October 2025

    

12. Image-guided cryoablation of soft-tissue metastases in patients with oligoprogressive disease: analysis of feasibility, safety, and efficacy

    • Nicos Fotiadis
    • Niaz Ahmed
    • Paris Tekkis

    in CVIR Oncology

    Article Open access 31 October 2025

    

13. Combination of approved chemotherapeutics and natural products for topoisomerase II targeting: efficacy and safety in cancer therapy

    • Ali H. El-Far
    • Ahmed Elfadadny
    • Junjiang Fu

    in Holistic Integrative Oncology

    Article Open access 30 October 2025

    

14. NT-I7, a novel long-acting interleukin-7, promotes anti-PD-1 efficacy in an autologous humanized melanoma model

    • Yee Peng Phoon
    • Alexandra A. Wolfarth
    • Brian R. Gastman

    in Scientific Reports

    Article Open access 30 October 2025

    

15. Dealmakers seek to expand the druggable proteome

    • Peter Kirkpatrick

    in Biopharma Dealmakers

    Article 30 October 2025

    

16. Reprogramming neural-tumor crosstalk: emerging therapeutic dimensions and targeting strategies

    • Qian-Qian Liu
    • Zi-Kai Dong
    • Wei-Lin Jin

    in Military Medical Research

    Article Open access 30 October 2025

    

17. HER2 as a molecular trojan horse in prostate cancer: mechanistic insights and therapeutic unlocks

    • Anirban Goutam Mukherjee
    • Abilash Valsala Gopalakrishnan

    in Molecular Biology Reports

    Article 30 October 2025

    

18. Integrative network pharmacology and experimental validation of multi-target synergy against multidrug-resistant klebsiella pneumoniae via PI3K/AKT-MAPK pathway disruption

    • Tian Man
    • Huiyong Yu
    • Chengxiang Wang

    in Naunyn-Schmiedeberg's Archives of Pharmacology

    Article 29 October 2025

    

19. Current Status and Advancements in Radiotheranostics and Targeted Radionuclide Therapy in Malaysia

    • Muhammad Fakhrurazi Ahmad Fadzil
    • Zarif Ashhar
    • Akram Al-Ibraheem

    in Nuclear Medicine and Molecular Imaging

    Article 29 October 2025

    

20. A Retrospective Observational Study of Extended Adjuvant Neratinib for HER2-Positive Early-Stage Breast Cancer in a European Early Access Program

    • Marija Križić
    • Tajana Silovski
    • Michelino De Laurentiis

    in Oncology and Therapy

    Article Open access 29 October 2025

    

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