Adaptive clinical trial

Latest research

1. CAUSALRLSTACK: adaptive balancing of deep representation and causal effect estimation with application to HIV-related health data

   • Dat Thanh Pham
   • Khai Quang Tran
   • Viet Anh Nguyen

   in BioData Mining

   Article Open access 05 November 2025

   

2. Sebetralstat: FDA approves first oral on-demand therapy for hereditary angioedema

   • Laiba Bibi
   • Hafsa Azam
   • Fatima Yaseen

   in Irish Journal of Medical Science (1971 -)

   Article 05 November 2025

3. Protocol for a cluster randomised controlled trial comparing structured Follow-up And Monitoring Of new USers of NHS hearing aids to usual care: the FAMOUS trial

   • Kevin J. Munro
   • Christopher Armitage
   • Bethany Gill

   in Trials

   Article Open access 05 November 2025

   

4. Outcomes of relapse after teclistamab therapy in multiple myeloma

   • Kyle L. Yu
   • Matthew Ho
   • Sandra Susanibar-Adaniya

   in Blood Cancer Journal

   Article Open access 05 November 2025

   

5. The PULSE Study: Paramedic Upgrade and Life Support Evaluation

   • Mark McGraw
   • Kavish Chandra
   • Paul Atkinson

   in Canadian Journal of Emergency Medicine

   Article 05 November 2025

6. PRO B-Studie – PRO-Monitoring bei fortgeschrittenem Brustkrebs

   • Maria M. Karsten
   • Therese Pross

   in Die Onkologie

   Article 04 November 2025

   

7. Adaptive Coverage Path Planning for Multiple Fixed-wing UAVs With Learning-based Initialization

   • Sukmin Yoon
   • Youngjung Kim
   • Tae Hyun Kim

   in International Journal of Control, Automation and Systems

   Article 04 November 2025

8. Risk-adapted venous thromboembolism prophylaxis in Asian patients admitted to medical intensive care unit: a prospective controlled trial

   • Peampost Sinsakolwat
   • Konlawij Trongtrakul
   • Chatree Chai-Adisaksopha

   in Thrombosis Journal

   Article Open access 04 November 2025

   

9. Development of the SAVE study protocol to use lived experience to assess the value of serious health-related suffering and palliative care

   • Afsan Bhadelia
   • Natalie Greaves
   • Felicia M. Knaul

   in Communications Medicine

   Article Open access 04 November 2025

10. Feasibility and acceptability of a parallel, two-arm randomized controlled trial to evaluate an online physical activity behavior counseling intervention for young adults diagnosed with cancer: a mixed-methods pilot study

    • Jennifer Brunet
    • Jenson Price
    • Amirrtha Srikanthan

    in Pilot and Feasibility Studies

    Article Open access 04 November 2025

    

11. AdaptFedDS: adaptive federated learning edge devices selection by using a light-dual reinforcement learning approach

    • Fazeleh Tavassolian
    • Mahdi Abbasi
    • M. Reza Khosravi

    in Cluster Computing

    Article 03 November 2025

    

12. Beyond statistical heterogeneity: physiological individualization in septic shock resuscitation. Authors' Reply

    • Matthieu Legrand
    • Romain Pirracchio

    in Intensive Care Medicine

    Article 03 November 2025

13. Methodological concerns regarding KEYNOTE-199: immortal time bias and treatment attribution challenges in combination immunotherapy

    • Zuomin Wang
    • Qinwei Liu
    • Wangdong Deng

    in Prostate Cancer and Prostatic Diseases

    Article 03 November 2025

    

14. Synthetic control arm from mixed clinical trials and real-world data from the LYSA group for untreated diffuse large B-cell lymphoma patients aged over 80 years: a bona fide strategy for innovative clinical trials

    • Valentin Letailleur
    • Isabelle Chaillol
    • Benoit Tessoulin

    in Blood Cancer Journal

    Article Open access 03 November 2025

    

15. Protocol for Fit4Transplant: iterative optimisation of an exercise prehabilitation service for haematological cancer patients using phase II adaptive trials and co-design

    • Camille E. Short
    • Lara Edbrooke
    • Linda Denehy

    in BMC Cancer

    Article Open access 03 November 2025

    

16. Clinical and ultrasound remission at 48 weeks of upadacitinib in rheumatoid arthritis: real-world results from the Italian multicenter UPARAREMUS study

    • Andrea Picchianti Diamanti
    • Valentino Paci
    • Annamaria Iagnocco

    in Arthritis Research & Therapy

    Article Open access 03 November 2025

    

17. Development and Evaluation of a Three-day Acceptance and Commitment Therapy-Based Resiliency Training Program for National Cancer Institute-Funded Investigators

    • Miryam Yusufov
    • William F. Pirl
    • Joseph A. Greer

    in Journal of Cancer Education

    Article 03 November 2025

18. Adaptive Reduced Multilevel Splitting

    • Frédéric Cérou
    • Patrick Héas
    • Mathias Rousset

    in Statistics and Computing

    Article 03 November 2025

    

19. Refining the use of neuromuscular blockade in ARDS: lessons from a post hoc Markov model re-analysis of the ACURASYS trial

    • Ines Lakbar
    • Audrey De Jong
    • Denise Battaglini

    in Intensive Care Medicine

    Article 03 November 2025

    

20. Early experience on omaveloxolone in adult patients with Friedreich’s ataxia: a real-world observational study

    • Salvatore Maria Lima
    • Marta Caltagirone
    • Vincenzo Di Stefano

    in Journal of Neurology

    Article Open access 01 November 2025

    

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