Achieving enantioselective construction of bridged-ring scaffolds presents a challenge, due to the considerable structural strain of the products and the presence of multiple stereocenters. Herein, the authors report a Pd/Cu co-catalyzed substrate-dependent enantiodivergent tandem Heck/Sonogashira reaction for synthesis of alkyne-tethered (R,S,S)-bicyclo[3.2.1]octenes and (S,R,R)-benzo-bicyclo[3.2.1]octanes, each featuring one quaternary and two adjacent tertiary stereocenters.

This study introduces P3T-Net, a pseudo-3D deep learning model that enables accurate and efficient cross-domain transfer of large 3D material images, improving image quality and ensuring image consistency across diverse imaging conditions.

Cobalt-zeolite catalysts for propane dehydrogenation (PDH) typically exhibit low activity due to the confined Co sites within the zeolite framework or poor stability of CoO_x species under hydrogen. Here, the authors demonstrate that anchoring CoO_x nanoclusters onto the 10 -membered rings of silicalite-1 significantly enhances PDH performance.

Color center magnetometry enables spin-wave imaging in complex magnetic textures. This work overcomes key limitations of current approaches by decoupling sensor spins from control fields and using diamond and hBN color centers for complementary frequency operation, achieving isofrequency imaging of field-controlled spin waves.

Electrochemical synthesis of solid compounds is an emerging frontier in electrocatalysis. Here, the authors report a Pt catalyst whose surface-coordinated halogens alleviate the scaling effect by regulating the local environment and enable simultaneous Mg(OH)â‚‚ and Hâ‚‚ production from natural seawater.

Ancient hyperthermals witnessed a reduction in the transfer efficiency of particulate organic carbon from the surface to the deep ocean due to warming-driven increases in microbial metabolism, which may have amplified this ancient warming.

Burned structures in wildfires release air pollutants not included in emissions inventories. Structure burning in wildland-urban interface fires emit hazardous compounds at levels exceeding anthropogenic sources in some US states.

Geochemical data reveals that volcanic pulses caused episodic climatic cooling from ~470 to 445 million years ago, driven by basalt weathering.

Super El Niño events greatly increase the likelihood of global climate regime shifts, revealing their amplified impact and risks in a warming world.

The Antarctic winter phytoplankton production is experiencing an underestimated acceleration based on the spaceborne LiDAR. This trend is linked to the declining sea ice, highlighting the Southern Ocean’s escalating role in the global carbon cycle.

Dysfunctional NK cells contribute to the immune-hostile tumour microenvironment of triple-negative breast cancers (TNBC). Here authors show that NKSM, a micropeptide encoded by the long non-coding RNA UGDH-AS1, is specifically expressed in the intra-tumoral NK cells in TNBC and interferes with their anti-tumour activity.

GM4951 is a GTPase in hepatic lipid metabolism. Here, the authors determine the atomic structure of GM4951, which forms a tail-to-tail dimer essential for lipid droplet localization. MASLD-linked mutations destabilize the protein and alter the dynamics of switch loops of the GTPase domain.

A shared neural feature space encoding self-generated autobiographical imagery and externally driven sentence semantics is revealed by decoding imagined autobiographical content from fMRI data with a model trained on semantic feature representations.

GlyContact enables systematic analysis of glycan 3D structures, revealing how structural properties like flexibility and surface accessibility determine lectin binding and introducing AI models to predict structural features directly from sequences.

Authors show that all individuals have asymmetrically glycosylated IgGs—the glycans on each of the Fc protomers are not identical. Asymmetrically monofucosylated IgGs drive dengue disease and are functionally similar to afucosylated IgGs.

Here, in a randomized clinical trial, the authors report that an experimental young child formula containing a combination of Limosilactobacillus reuteri DSM 17938 and galacto-oligosaccharides enhances bone and muscle development in early life through modulation of the microbiome.

Here, the authors characterize the gut virome of 647 one-year-old children in the COPSAC2010 cohort, finding that anelloviruses are highly prevalent and associated with daycare attendance, gestational age, and FUT2 secretor status.

Diabetes, a frequent co-morbidity to osteoarthritis, accelerates progression of joint inflammation. Here author show that hyperglycaemia enhances glycolysis in synovial macrophages, leading to increased lactylation of CD11b, which impairs the capacity of macrophages to phagocytose apoptotic cells, which eventually aggravates inflammation.

Psychological distress is associated with a range of adverse outcomes in people living with and beyond cancer (LWBC). In here, the authors find that psychological distress is associated with an increased risk of all-cause and cancer mortality in people with LWBC, partly due to high systemic inflammation. However, evidence for mediation by health behaviours is found to be inconsistent.

Pathology foundation models can still struggle with generalizability and fairness across demographic groups. Here, the authors develop FLEX, a framework to enhance cross-domain generalization and demographic fairness in pathology foundation models, improving performance and mitigating disparities in cancer datasets.

SDG 6.1 on drinking water lags behind, while rainwater holds future potential to address this goal. A parametric framework proposes a comprehensive stepwise roadmap demonstrating rainwater could provide safe drinking water for 0.45–2.08 billion people.

Understanding others’ emotions is central to human connection. Here, the authors show that people systematically overestimate others’ emotional intensity, especially for negative emotions, a tendency that may promote empathy and relationship satisfaction.

LLMs struggle to reliably identify mis/disinformation content, raising concerns about information governance. This study presents two Chinese datasets of AI-generated mis/disinformation and uncovers key linguistic features affecting their quality and detection.

By incorporating spatial and social networks, this study captures the real-world spread of electric vehicle adoption across communities more accurately and highlights the substantial uncertainties in long-term adoption forecasts.

The research explores how ultrasound-based human-machine interfaces generalize across a wide variety of situations and participants. Robustness was achieved, with new users able to control virtual hands without the need for calibration.