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STAT3 S727 phosphorylation drives pathogenic Th17 differentiation and neuroinflammation in autoimmune disease Douglas S. PradoAchyudhan R. KutuvaWilliam F. Hawse Research Open access 28 October 2025 Article: 246
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The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration Henry KurniawanSarah L. NickelsJens C. Schwamborn Research Open access 27 October 2025 Article: 244
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The NOX2-ROS-NLRP3 inflammasome axis in traumatic brain injury Janeen LaabeiGloria VeglianteDavid J. Loane Research Open access 27 October 2025 Article: 242
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Retraction Note: Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage Yucong PengJianfeng ZhuangGao Chen Retraction Note Open access 16 October 2025 Article: 236
cGAS-STING signaling in brain aging and neurodegeneration: molecular links and therapeutic perspectives Huayu LiRuixin CaiSijie Tan Review Open access 15 October 2025 Article: 235
Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage Sahily Reyes-EstevesAparajeeta MajumderJacob S. Brenner Research Open access 14 October 2025 Article: 234
IL-1β+ tumor-associated macrophages accelerate glioblastoma progression by amplifying the PGE2-EP4 signaling Hao LiangQunying YangHui Peng Research Open access 14 October 2025 Article: 233
Assessment of intestinal barrier integrity and associations with innate immune activation and metabolic syndrome in acutely ill, antipsychotic-free schizophrenia patients Kaushiki MukherjeePaul C. GuestJohann Steiner Research Open access 13 October 2025 Article: 232
Early immune responses to systemic inflammation in the postnatal mouse brain initiated by migrating macrophages and leptomeningeal fibroblasts Rei SettsuAki ObaraAtsuyoshi Shimada Research Open access 11 October 2025 Article: 231
MMPs and NETs are detrimental in CNS-tuberculosis with MMP Inhibition in CNS-tuberculosis mice improving survival Xuan Ying PohFei Kean LohCatherine W. M. Ong Research Open access 11 October 2025 Article: 230
Transcriptomic profiling of thrombus-derived extracellular vesicles reveals PECAM-1 as a potential inflammatory marker for cardioembolic stroke patients Florencio J. D. MachadoJuan Marta-EnguitaJosune Orbe Research Open access 09 October 2025 Article: 229
Early antiviral treatment following gammaherpesvirus-68 infection of the central nervous system prevents subsequent multiple sclerosis-like disease Alexander MuselmanSameera KongaraEdgar G. Engleman Research Open access 08 October 2025 Article: 228
A neuroimmune cerebral assembloid model to study the pathophysiology of familial Alzheimer’s disease Andrea Becerra-CalixtoAnik BanerjeeJuneyoung Lee Research Open access 08 October 2025 Article: 227
T cell-mediated SIV dissemination into the CNS: a single-cell transcriptomic analysis Xiaoke XuMeng NiuHoward S. Fox Research Open access 08 October 2025 Article: 226
NLRP3 inflammasome and hearing loss: from mechanisms to therapies Silvia Murillo-CuestaElena SeoaneIsabel Varela-Nieto Review Open access 04 October 2025 Article: 225
Cytokine expression profile in the human brain of older adults Juliana Beker GodoyRicardo A. VialleKatia de Paiva Lopes Research Open access 03 October 2025 Article: 224
Microglial glycolytic reprogramming in alzheimer’s disease: association with impaired phagocytic function and altered vascular proximity Ning LuZhongman JinQi Xu Research Open access 02 October 2025 Article: 223
Neuro-immune regulation of sepsis-associated delirium via the PBN-CeA-spleen axis Menglin DongYu ZouQianyi Peng Research Open access 02 October 2025 Article: 222
Cerebrospinal fluid neuronal pentraxin levels are associated with tau pathology via microglia–astrocyte signaling in alzheimer’s disease Zihao ZhangXin ChenWen-Quan Zou Research Open access 02 October 2025 Article: 221
Salt-sensitive hypertension promotes neuronal mitochondrial stress and neurodegenerative alterations via neuro-vascular metabolic reprogramming and local RAS signaling Hanxue WuZihan QiuJiaxi Xu Research Open access 02 October 2025 Article: 220
Interferon-induced GTP-binding protein MX1 drives hyperexcitability in peripheral nerves: a novel mechanism in small fiber neuropathy Amanda C.Y. ChanHua HuangHerbert Schwarz Research Open access 01 October 2025 Article: 219
Modular inflammation network discovery from large-scale phenotypic screening in genetically heterogeneous mouse brains Monica XiongLisa A. MiosgeChristopher J. Bohlen Research Open access 29 September 2025 Article: 218
Cholecystokinin ameliorates cognitive impairment via inhibiting microglia phagocytosis of excitatory synapses in sepsis-associated encephalopathy mice Lei ChenZhen LiTaotao Liu Research Open access 29 September 2025 Article: 217
Dysregulation of cellular metabolism within the gut-brain axis is associated with behavioural changes in chronic intestinal inflammation Jeannie DevereauxAinsley M. RobinsonKulmira Nurgali Research Open access 26 September 2025 Article: 216
Eosinophil recruitment and activation in the central nervous system of patients with subarachnoid neurocysticercosis Emily MiltenbergerJanitzio GuzmánElise M. O’Connell Research Open access 26 September 2025 Article: 215
Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner Jiahui LiuAli ZaidiChristian J. Pike Research Open access 26 September 2025 Article: 214
LncBADR promotes T cell-mediated autoimmunity by binding Mccc1 and Pcca to regulate BCAAs degradation Yanting LeiJing YuBo Sun Research Open access 26 September 2025 Article: 213
Macrophage expression of P2X7 controls autoimmune uveitis Paul-Alexandre Déchelle-MarquetYueshen CheCécile Delarasse Research Open access 25 September 2025 Article: 212
Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation Qingyu RenZhanpeng GaoJinhao Sun Research Open access 24 September 2025 Article: 211
Knockout of P2Y12 receptor facilitates neuronal envelopment by reactive microglia and accelerates prion disease Natallia MakaravaTarek SafadiIlia V. Baskakov Research Open access 31 August 2025 Article: 210
Circulatory extracellular vesicles transport complement C1q for promoting neuronal amyloid-β production in Alzheimer’s disease Yang YuWenjun XiaoZhigang Li Research Open access 29 August 2025 Article: 209
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage Peng-Fei DingJia-Tong ZhangWei Li Research Open access 28 August 2025 Article: 208
Disrupted betaine metabolism drives Th17 cell differentiation, mediating methamphetamine-induced depressive behaviors in male mice Rongji HuiJiabao XuDi Wen Research Open access 26 August 2025 Article: 207
TLR9/NF-κB-mediated dendritic cell activation by neutrophil extracellular traps drives pathogenesis in experimental cerebral malaria Shijie YaoYan ZhaoYaming Cao Research Open access 26 August 2025 Article: 206
Single−cell transcriptomic landscape of sciatic nerve after transection injury Yiben OuyangMingqian YuYu Wang Research Open access 23 August 2025 Article: 205
Genetic polymorphisms in human CX3CR1-mediated macrophage dysregulation are associated with the worsening of hearing loss and cochlear degeneration after noise trauma: a study in a humanized mouse model Dinesh Y. GawandeSree Varshini MuraliTejbeer Kaur Research Open access 16 August 2025 Article: 204
Cystatin F-a key player in central nervous system disease Yi-Ting WangQiang LiKe Zhang Review Open access 14 August 2025 Article: 203
Inhibition of astrocyte signaling leads to sex-specific changes in microglia phenotypes in a diet-based model of cerebral small vessel disease Jenna L. GollihueKhine Zin AungChristopher M. Norris Research Open access 09 August 2025 Article: 202
CRTH2 is critical for IL-1β-producing B cells during experimental autoimmune encephalomyelitis in mice via p38 signaling Jiao LiuBei WangShengkai Zuo Research Open access 08 August 2025 Article: 201
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