Correction: Discovery of therapeutic AGC2 modulators by combining docking, binding, and vesicle-based transport assays Lucas Cafferati BeltrameSabino TodiscoCiro Leonardo Pierri Correction Open access 29 October 2025 Article: 1194
Integrated multi-omics reveals glycolytic gene signatures of lung adenocarcinoma brain metastasis and the impact of Rac2 lactylation on immunosuppressive microenvironment Yali YiWenjie XuAnwen Liu Research Open access 29 October 2025 Article: 1193
Insights into spheroid formation: interaction of ovarian cancer cells with macrophage populations in the tumor microenvironment Simone PisanoYajaira Sofia JimenezBruna Corradetti Research Open access 29 October 2025 Article: 1192
BRCAGenie: A machine learning-driven 43-gene polygenic risk score model for precision prediction of breast cancer survival Jia Wei LeeAshley Jun Wei LimCaroline G. Lee Research Open access 29 October 2025 Article: 1191
Immunometabolic reprogramming in lung cancer: interplay between immune and stem-like cells in immune checkpoint inhibitor resistance Ji-Yong SungEui Tae Kim Review Open access 29 October 2025 Article: 1190
Mechanistic insights into SLAMF8-mediated prostate cancer metastasis via the TLR4-NF-κB pathway Qiang SuZhao LiBin Dai Research Open access 29 October 2025 Article: 1189
SpateCV: cross-modality alignment regularization of cell types improves spatial gene imputation for spatial transcriptomics Jiaqi YuanJunhua YuWenbin Liu Research Open access 29 October 2025 Article: 1188
TRIM32 promotes tumor immune evasion and impedes Anti–PD-1 treatment by inducing immunosuppressive macrophages in gastric cancer Changming WangXujun ZhuQingping Cai Research Open access 29 October 2025 Article: 1187
CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway Bo-han LiLing LiuDe-fang Li Research Open access 29 October 2025 Article: 1186
Factors affecting survival in patients with colorectal cancer: an umbrella review Lulin YuJing YuanLeitao Sun Research Open access 29 October 2025 Article: 1185
CT radiomic stratification signature to optimize clinical decisions for ovarian cancer patients receiving neoadjuvant chemotherapy and the underlying biological basis: a multicenter retrospective study Shimin ZhangXinyue LiXin Zhou Research Open access 28 October 2025 Article: 1184
Panmim: a resource of pan-cancer metastasis immune microenvironment Xuelu ZhangSimeng HuLu Zheng Research Open access 28 October 2025 Article: 1183
New power in cancer immunotherapy: the rise of chimeric antigen receptor macrophage (CAR-M) Jiajie JingYueming ChenChunjing Xu Review Open access 28 October 2025 Article: 1182
Which dominates recurrence: tumor or microenvironment? Guoqing LyuXin DengJincheng Guo Commentary Open access 28 October 2025 Article: 1181
Interaction effect of age and axial length-to-corneal radius ratio on myopia in children and adolescents: a cross-sectional study in China Jingfeng MuHaoxi ZhongMingjie Jiang Research Open access 28 October 2025 Article: 1180
The GPX3 rs3828599 genotype in combination with alcohol consumption and age helps identify a high-risk hypertension subgroup for antioxidant intervention Zhongjie XieBaogang WuYing Hao Research Open access 28 October 2025 Article: 1179
Analysis of the efficacy and influencing factors of double-dose furmonertinib for advanced EGFR ex20ins non-small cell lung cancer Kexin ZhangYi GeLiping Wang Research Open access 27 October 2025 Article: 1178
Mechanism by which CAP regulates the “cold–heat” balance in osteosarcoma model mice: an integrative study of metabolomics, transcriptomics, and network pharmacology Ziming WangShun ZhangYang Wang Research Open access 27 October 2025 Article: 1177
Transformative advances in single-cell omics: a comprehensive review of foundation models, multimodal integration and computational ecosystems Taylor YiuBin ChenHuijing Hu Review Open access 27 October 2025 Article: 1176
Immunoglobulin G N-glycosylation predicts long-term risk of ischemic stroke: a nested case-control study Shuyu SunJiheng HaoHaifeng Hou Research Open access 27 October 2025 Article: 1175
Implementation of precision medicine in treating non-communicable diseases: a systematic review Shuang LiangElizabeth KennedyNatalie Taylor Review Open access 27 October 2025 Article: 1174
Computerized cognitive training enhances cognitive function in Alzheimer’s disease by downregulating Ruminococcus-TMAO pathway Wenbo ZhangJiaqi SongYang Lü Research Open access 24 October 2025 Article: 1173
Letter to Editor: Postbiotics as a novel intervention for obesity management and improving metabolic parameters: a systematic review and meta-analysis of animal studies Mahdieh Khodarahmi Letter to the Editor Open access 24 October 2025 Article: 1172
Nano-therapeutics targeting the macrophage-based microenvironment in the treatment of atherosclerosis Yingjie XuYuan ZhangWanpeng Yu Review Open access 24 October 2025 Article: 1171
Akkermansia muciniphila: a microbial guardian against oxidative stress–gut microbiota crosstalk and clinical prospects Wen-Yu YeYan Cai Review Open access 24 October 2025 Article: 1169
A comment on “Acute effects of a single bout of high-intensity strength and endurance exercise on cognitive biomarkers in young adults and elderly men: a within-subjects crossover study” Jiaojiao ShenXiangyang Mei Letter to the Editor Open access 24 October 2025 Article: 1168
Comment to “Proteomic analysis of human kidney biopsies unveils emerging acute kidney injury very early after liver graft reperfusion” Tao ChenTao Luo Letter to the Editor Open access 24 October 2025 Article: 1167
Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling Xiuting HuangYuan ZhuangYan Yan Research Open access 24 October 2025 Article: 1166
Comments on “Association of systemic immune-inflammation index with adverse outcomes in heart failure and preserved ejection fraction” Jiaxin ShaoCaifeng ZhuJiazhen Yin Letter to the Editor Open access 23 October 2025 Article: 1165
USP21/YBX1/HIF1-α promotes the progression of prostate cancer Zhuoran GuLibin ZouXudong Yao Research Open access 23 October 2025 Article: 1164
CAR-T and CAR-NK cell therapies in AML: breaking barriers and charting the future Huichao WuFatemeh Sadat ShafieiHamed Soleimani Samarkhazan Review Open access 23 October 2025 Article: 1163
Ruminococcus torques ameliorates the inflammation bowel disease and gut barrier dysfunction by modulating gut microbiota and bile acid metabolism Yue LouYao LvYan Ni Research Open access 23 October 2025 Article: 1162
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveal macrophage subpopulation characteristics and the role of STAT1 in rheumatoid arthritis Lulu YeXinlin HuangAn Huang Research Open access 23 October 2025 Article: 1161
Muscle quality decline and fat infiltration in non-elderly OSA patients: associations with metabolic abnormalities Dasheng LuMingchao ZhangHao Zhang Research Open access 23 October 2025 Article: 1160
Plasma multi-omics and machine learning reveal predictive biomarkers for type 2 diabetes and retinopathy in Qatar biobank cohort Ikhlak AhmedAjaz A. BhatAmmira Al-Shabeeb Akil Research Open access 22 October 2025 Article: 1159
Magnetic resonance imaging quantifies causal body compartment effects on metabolic traits via immune phenotypes—a Mendelian randomisation study Di ZhangLiang-ping LiXin-yu Huang Research Open access 22 October 2025 Article: 1158
Regulation of macrophages in the dorsal root ganglion through TGF-β1 inhibits painful traumatic neuroma Chuanpeng XiaJinghao LiangHede Yan Research Open access 21 October 2025 Article: 1157
Hidden risk factors for recurrence of jejunoileal Gastrointestinal stromal tumors with low NIH classification: implications for surveillance and adjuvant therapy Xiangfei SunYinwen SunPing Shu Research Open access 21 October 2025 Article: 1156
Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs) Pooria Safarzadeh KozaniPouya Safarzadeh Kozani Review Open access 21 October 2025 Article: 1155
Exosomal circDNAJB6 derived from decidual macrophages promotes preeclampsia progression via the miR-670-5p/TOB2 axis and by subsequently regulating the PPARγ/NF-κB pathway Lu ZhangXijia TianHui Zhang Research Open access 21 October 2025 Article: 1154
Glioblastoma resistance to EGFR antibody-drug conjugate is driven by transcriptional reprogramming and TEK-induced EGFR suppression Mylan R. BlomquistTeresa M. R. NovielloNhan L. Tran Research Open access 21 October 2025 Article: 1153
Renal cell carcinoma organoids for precision medicine: bridging the gap between models and patients Jian GaoHuijiu LuoShulian Chen Review Open access 21 October 2025 Article: 1152
Could artificial intelligence accelerate progress in ambulatory anesthesia? Alessandro VittoriMarco Cascella Commentary Open access 21 October 2025 Article: 1151
ITGB5-mediated biomechanical regulation in pancreatic ductal adenocarcinoma stroma impacts tumor progression and prognosis Aoran YangChengli GuYu Shi Research Open access 21 October 2025 Article: 1150
Strain-level characterization of bacterial pathogens using metagenomic sequencing for patients with pneumonia Hua ZhouXi LiYe Feng Research Open access 21 October 2025 Article: 1149
Low-dose rapamycin alleviates clinical symptoms of fatigue and PEM in ME/CFS patients via improvement of autophagy: a pilot study Brian T. RuanSarojini BulbuleC. Gunnar Gottschalk Research Open access 21 October 2025 Article: 1148
Revisiting the impact of cathepsin Z in prostate cancer: concerns and insights Zhiguo ZhuHuisheng QinZhonghai Li Letter to the Editor Open access 21 October 2025 Article: 1147
SorCS3 suppresses adrenocortical carcinoma progression by enhancing IGF2R-mediated endocytic trafficking and signaling attenuation Yanqiu ZhangShihui CaoDongliang Li Research Open access 21 October 2025 Article: 1146
Bridging metabolism and immuno-inflammation: a novel framework to characterize dilated cardiomyopathy subtype Cheng YuChanghu LiuJing Yuan Research Open access 21 October 2025 Article: 1145
Pbk positively regulates myoblast differentiation and muscle regeneration via enhancing AMPK/ULK1 mediated myogenic autophagy Dongdong WangDidi ShanChuanzhu Yan Research Open access 21 October 2025 Article: 1144
