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Construction and validation of a lactylation-based gene signature for prognostic assessment and immune infiltration analysis in gastric adenocarcinoma Yu ZengGaojian ZhuangJialin Chen Research Open access 14 October 2025 Article: 160
Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitis Feixiang ZhuMingyan XuXiaoling Deng Research Open access 14 October 2025 Article: 159
Three intronic variants altering RNA splicing were identified in the CLCN5 gene by minigene assay Dan QiaoXuyan LiuLeping Shao Research Open access 14 October 2025 Article: 158
An intron SNP rs666088 in SLIT2 increases the risk of acute coronary syndrome in an Iranian population Pooria PakdamanNadereh NaderiMahsa Rahimzadeh Research Open access 14 October 2025 Article: 157
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Molecular mechanisms underlying the co-pathogenesis of abdominal aortic aneurysm and rheumatoid arthritis: evidence based on bioinformatics analysis and clinical data Youfu WangLing ZhangXiao Qin Research Open access 09 October 2025 Article: 155
The role of genetic polymorphisms on drug response in Alzheimer’s disease: a systematic review Fresthel Monica M. ClimacosaEric David B. OrnosVeeda Michelle M. Anlacan Research Open access 09 October 2025 Article: 154
CASC15 participated in the damage of vascular endothelial cells in atherosclerosis through interaction with miR-940 Tairan LiZhaolan YangMeng Li Research Open access 07 October 2025 Article: 153
Alcohol exposure significantly influences gene expression in the hypothalamus, highlighting complex links with gonadotropin-releasing hormone signaling and thyroid hormone production in adolescent mice Guangtao SunYujing PengYuling Jin Research Open access 07 October 2025 Article: 152
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Wiedemann-Steiner syndrome: description of genetic profiles and clinical phenotypes of 10 Korean pediatric patients Jeesun YooA Young ParkJung Min Ko Research Open access 06 October 2025 Article: 149
Bone marrow mesenchymal stem cell-derived exosomes attenuate hepatic stellate cell activation through miR-223-3p-mediated mitophagy Lijie MaWeidong WengFengbin Lu Research Open access 03 October 2025 Article: 148
An ADR pharmaceutical care for severe gastrointestinal bleeding of rivaroxaban in a patient with nonvalvular atrial fibrillation based on TDM and genetic testing: a case report Youqi HuangHongjin GaoMin Chen Case Report Open access 03 October 2025 Article: 147
Mono-allelic MUTYH mutation as the likely inherited etiology of hereditary breast cancer in a patient from a multi-cancer family- report of a family and literature review Akram SarmadiShaghayegh Haghjooy JavanmardMohammad Amin Tabatabaiefar Research Open access 01 October 2025 Article: 146
Development of a prognostic model based on seven mitochondrial autophagy- and ferroptosis-related genes in lung adenocarcinoma Ya-nan ZhaoHai-yang LiBo-feng Hou Research Open access 01 October 2025 Article: 145
Impact of interaction between IL-21 gene variants and smoking status on susceptibility to rheumatoid arthritis Xiang LuYuan XueShanle Yan Research Open access 30 September 2025 Article: 144
Advanced glycation end-product receptor gene (RAGE) polymorphisms in patients with acute coronary syndrome – a case-control study in the Polish population Klaudia GutowskaMichał AmbroziakAlina Kuryłowicz Research Open access 30 September 2025 Article: 143
Fatty acid metabolism in ischemic stroke: multi-omics biomarker discovery and therapeutic potential of GPR84 Jun WuDa WuKuan Jiang Research Open access 30 September 2025 Article: 142
Exploration and validation of the immune-related genes signatures and potential molecular mechanisms shared between Alzheimer’s disease (AD) and Parkinson’s disease (PD) Kaige ZhouJingxing ZhangYunping Song Research Open access 30 September 2025 Article: 141
Identification and validation of the cellular senescence-associated molecular pattern and diagnostic markers for osteoporosis Tengyan LiuJiashuang FanLifen Dai Research Open access 02 September 2025 Article: 140
Inherited retinal diseases in Kentucky: diagnostic yield, gene variants, and novel mutations in a U.S. population Nicholas DemasCesar EstradaRamiro Maldonado Research Open access 28 August 2025 Article: 139
Identification of an F8 complex recombination in Chinese hemophilia a patient using long-read sequencing and optical genome mapping Yuxin ZhangMingjie YangHaibo Li Research Open access 27 August 2025 Article: 138
Tracking of multidrug-resistant pathogen clones in Ghana: a systematic review and meta-analysis Alex OdoomEric S. Donkor Research Open access 27 August 2025 Article: 137
Association of IL-10, IL-6, and TNF-α polymorphisms with acute coronary syndrome risk: a systematic review, meta-analysis, and trial sequential analysis Yang LuoShiqi LiShasha Shi Systematic Review Open access 23 August 2025 Article: 136
First report of Leishmania RNA virus 2 and its high genetic diversity in cutaneous leishmaniasis cases from Ilam Province, Iran Reza SaberiAmirmohammad Fallahi LimaMahdi Fakhar Research Open access 21 August 2025 Article: 135
CUX1 variant and 9p deletion: expanding the spectrum and resolving variable GDD/ID in a family Haiting LiuXiaoyong LiuShuyao Zhu Research Open access 20 August 2025 Article: 134
CCDC82 and neurodevelopment: a novel genetic variant linked to infantile spasms and hypotonia Zahra SafarianShiva MehrabiNahid Rezaie Research Open access 20 August 2025 Article: 133
The changes of immune function after neuroblastoma chemotherapy and the prediction of potential immune targets Yunfei MaYan SuXin Ni Research Open access 20 August 2025 Article: 132
Long read whole genome sequencing-based discovery of structural variants and their role in aetiology of non-syndromic autism spectrum disorder in India Jhanvi ShahDebasrija MondalHarsh Sheth Research Open access 20 August 2025 Article: 131
Correction: LIMA1 inhibits cisplatin resistance and malignant biological behavior of bladder cancer cells by suppressing the Wnt/β-catenin pathway Zhong LvShuchen ZhaoHaoran Wu Correction Open access 14 August 2025 Article: 130
The mitochondrial hub gene UCHL1 May serve as a potential biomarker for diagnosing diabetic cardiomyopathy: a comprehensive integration of biological pathways Chengjie GaoYijing TaoYafeng Zhou Research Open access 11 August 2025 Article: 129
Arsenic sulfide alleviates the progression of liver cancer malignancy by inhibiting the expression of TLCD1 in mice Xianglu LiXuehua XingShizong Li Research Open access 09 August 2025 Article: 128
Blood cell perturbation responses mediate the causal relationship between the gut microbiota and asthma: a bidirectional Mendelian randomization study Junjie BiLiqun ZhaoWei Zhang Research Open access 06 August 2025 Article: 127
Correction: Clinical characterizations and molecular genetic study of two co-segregating variants in PDZD7 and PDE6C genes leading simultaneously to non-syndromic hearing loss and achromatopsia Zahra NouriAkram SarmadiMohammad Amin Tabatabaiefar Correction Open access 04 August 2025 Article: 126
Molecular landscape of non-driver genes in myeloproliferative neoplasms through 333 cancer genes panel: Insights to reveal in Pakistan Munazza RashidRifat Zubair AhmedMuhammad Nadeem Asghar Research Open access 04 August 2025 Article: 125
Single-cell sequencing-based study of ferroptosis mechanisms in heat stroke: identification of key biomarkers and dynamic analysis of the immune microenvironment Defeng YinQin GuoYingchun Hu Research Open access 31 July 2025 Article: 124
A lipid metabolism-related gene signature predicts prognosis after tamoxifen treatment in ER + breast cancer and reflects tumor microenvironment heterogeneity through single-cell analysis Linxiaoxi MaBei QianHao Shen Research Open access 31 July 2025 Article: 123
Cost-effective promoter methylation analysis via target long-read bisulfite sequencing: a case study in severe preterm birth Silvana PereyraAngela SardinaMónica Cappetta Research Open access 29 July 2025 Article: 122
Epigenomic signatures of accelerated epigenetic aging are associated with congenital heart disease in newborns Kristen KocherJulius NgwaNickie Andescavage Research Open access 28 July 2025 Article: 121
Enrichment of tandem repeat element variants near CHD genes identified by short- and long-read genome sequencing Abhilash SureshSarah U. Mortonthe Pediatric Cardiac Genomics Consortium Research Open access 25 July 2025 Article: 120
The prognostic significance and Immunomodulatory role of SCGB3A1 expression in stage I lung adenocarcinoma Xin ZhangShiNing LiYi Hu Research Open access 21 July 2025 Article: 119
