Abstract
Cytosol and nuclear estrogen receptors and cytosol progesterone receptors were measured in 17 primary breast tumors and compared with sex chromatin frequencies. In cases with sex chromatin frequencies of greater than 20% there were 7/7 tumors with cytosol estrogen and progesterone receptors, 6/7 with cytosol and nuclear estrogen receptors, and 6/7 with all 3 receptors. This high proportion of receptor positive cases was not observed at lower sex chromatin frequencies. Sex chromatin frequencies in all the cytosol estrogen and progesterone receptor positive tumors were significantly higher (p < 0.05) than in the receptor negative tumors. Sex chromatin frequencies were not significantly different in the other groups. Our results suggest a possible association between the presence of steroid hormone receptors and sex chromatin frequencies of greater than 20%.
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References
McGuire W.L., Horwitz K.B., Pearson O.H., Segaloff A. Current status of oestrogen and progesterone receptors in breast cancer. Cancer 39: 2934, 1977.
King R.J.B., Redgrave S., Hayward J.L., Millis R.R., Rubens R.D. The measurement of receptors for oestradiol and progesterone in human breast tumours. In: King R.J.B. (Ed.), Steroid receptor assays in human breast tumours. Alpha-Omega Publishing, Cardiff, 1979, p. 55.
Barnes D.M., Skinner L.G., Ribeiro G.G. Triple hormone-receptor assay: a more accurate predictive tool for the treatment of advanced breast cancer? Br. J. Cancer 40: 862, 1979.
Kimel V.M. Clinical cytological correlations of mammary carcinoma based upon sex chromatin counts. Cancer 10: 922, 1957.
Bohle A., Burger E., Fischbach H., School-Tubingen H. Die Betentung der Barrschen Korperchen beim Mamm Carcinom. Arch. Klin. Chir. 313: 392, 1965.
Perry M. Evaluation of breast tumour sex chromatin (Barr body) as an index of survival and response to pituitary ablation. Br. J. Surg. 59: 731, 1972.
Rosen P.P., Savino A., Mendez-Botet C., Urban J.A., Mike V., Schwartz M.K., Melamed M.R. Barr body distribution and estrogen receptor protein in mammary carcinoma. Ann. Clin. Lab. Sci. 7: 491, 1977.
Rajeswari S., Ghosh S.N., Shah P.N., Borah V.J. Barr body frequency in the human breast cancer tissue. Eur. J.Cancer 13: 99, 1977.
Bishun N.P., Smethurst M., Williams D.C. The relationship between Barr bodies and cytoplasmic oestradiol receptors in human breast cancer. Clin. Oncol. 5: 147, 1979.
Atkin N.B. Triple sex chromatin and other sex chromatin anomalies in tumours of females. Br. J. Cancer 21: 40, 1967.
King R.J.B., Hayward J.L., Kumaoka S., Yamamoto H. Comparison of soluble oestrogen and progestin recep tor content of primary breast tumours from Japan and Britain. Eur. J. Cancer 13: 967, 1977.
Garola R.E., McGuire W.L. An improved assay for nuclear oestrogen receptor in experimental and human breast cancer. Cancer Res. 37: 3333, 1977.
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Smethurst, M., Bishun, N.P., Fernandez, D. et al. Steroid hormone receptors and sex chromatin frequency in breast cancer. J Endocrinol Invest 4, 455–457 (1981). https://doi.org/10.1007/BF03348311
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DOI: https://doi.org/10.1007/BF03348311