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The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review

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Natural Products and Human Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 1328))

Abstract

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The paper aims to review the current clinical evidence of various herbal agents as an adjunct treatment in the management of chronic periodontitis patients. Gingivitis and periodontitis are two common infectious inflammatory diseases of the supporting tissues of the teeth and have a multifactorial etiology. An important concern about chronic periodontitis is its association with certain systemic disease. New treatment strategies for controlling the adverse effects of chronic periodontitis have been extensively assessed and practiced in sub-clinical and clinical studies. It has been shown that the phytochemical agents have various therapeutic properties such as anti-inflammatory and antibacterial effects which can be beneficial for the treatment of periodontitis. The findings of this review support the adjunctive use of herbal agents in the management of chronic periodontitis. Heterogeneity and limited data may reduce the impact of these conclusions. Future long-term randomized controlled trials evaluating the clinical efficacy of adjunctive herbal therapy to scaling and root planing are needed.

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Authors and Affiliations

  1. Dental Research Center, Department of Periodontics, Dental Research Institute, Isfahan University of Medical sciences, Isfahan, Iran

    Omid Fakheran & Abbasali Khademi

  2. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Mohammad Bagherniya

  3. Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull, United Kingdom

    Thozhukat Sathyapalan

  4. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  5. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  6. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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  1. Omid Fakheran
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  2. Abbasali Khademi
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  3. Mohammad Bagherniya
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  4. Thozhukat Sathyapalan
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  5. Amirhossein Sahebkar
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Correspondence to Amirhossein Sahebkar .

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  1. Pharmacy, Medical Biotechnology, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  2. Diabetes, Endocrinology & Metabolism, The University of Hull, Brough, UK

    Thozhukat Sathyapalan

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Fakheran, O., Khademi, A., Bagherniya, M., Sathyapalan, T., Sahebkar, A. (2021). The Effects of Nutraceuticals and Bioactive Natural Compounds on Chronic Periodontitis: A Clinical Review. In: Sahebkar, A., Sathyapalan, T. (eds) Natural Products and Human Diseases. Advances in Experimental Medicine and Biology(), vol 1328. Springer, Cham. https://doi.org/10.1007/978-3-030-73234-9_5

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