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Antioxidant Activities and Redox Regulation of Interferon-Gamma-Induced Tryptophan Metabolism in Human Monocytes and Macrophages

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Tryptophan, Serotonin, and Melatonin

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 467))

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This article summarises studies supporting the proposal that induction of L-tryptophan (Trp) degradation along the kynurenine pathway in human monocytes and macrophages by interferon-γ (IFNγ) represents a novel extracellular antioxidant defence that acts to prevent inadvertent oxidative damage to host tissue during inflammation. The studies show that formation and release of the aminophenolic antioxidant 3-hydroxyanthranilic acid (3-HAA) is responsible for the ability of IFNγ-primed human macrophages to inhibit the oxidation of low density lipoprotein (LDL); an event implicated as an important event in atherogenesis. 3-HAA efficiently inhibits LDL oxidation by acting as an aqueous oxidant scavenger and a Synergist for LDL-associated vitamin E. Indoleamine 2,3-dioxygenase activity (IDO) is the initial and rate limiting enzyme of Trp degradation along the kynurenine pathway. Nitric oxide inhibits IDO activity in IFNγ-primed human macrophages and this may represent a physiological regulatory mechanism of the dioxygenase during inflammation.

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Authors and Affiliations

  1. The Biochemistry Group, The Heart Research Institute, 145 Missenden Rd., NSW, 2050, Sydney, Australia

    Shane R. Thomas & Roland Stocker

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  1. Shane R. Thomas
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  2. Roland Stocker
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Editors and Affiliations

  1. Department of Psychiatry, University of Göttingen, Göttingen, Germany

    Gerald Huether

  2. Department of Clinical Chemistry, University of Heidelberg, Heidelberg, Germany

    Walter Kochen

  3. Department of Food Chemistry, University of Hamburg, Hamburg, Germany

    Thomas J. Simat

  4. Department of Food Chemistry, University of Hamburg, Hamburg, Germany

    Hans Steinhart

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© 1999 Springer Science+Business Media New York

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Thomas, S.R., Stocker, R. (1999). Antioxidant Activities and Redox Regulation of Interferon-Gamma-Induced Tryptophan Metabolism in Human Monocytes and Macrophages. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_67

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  • DOI: https://doi.org/10.1007/978-1-4615-4709-9_67

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