Cytokine Mediated Regulation of Interferon-Gamma-Induced Ido Activation

MacKenzie, Colin R.; González, Raquel Guadarrama; Kniep, Eva; Roch, Simone; Däubener, Walter

doi:10.1007/978-1-4615-4709-9_66

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 467))

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Abstract

Stimulation of human monocyte-derived-macrophages (MDM) with interferon gamma induces the l-tryptophan degrading enzyme indoleamine 2,3-dioxygenase (IDO). It has been well documented that the growth of some intra-cellular parasites such as Chlamydia and Toxoplasma in human fibroblasts and glioblastoma cells is inhibited by IDO mediated L-tryptophan depletion. We have recently shown that IDO induction in cord blood MDM is also responsible for the growth inhibition of extra-cellular group B streptococci and thus for the first time shown an anti-bacterial effect of IDO activation. In view of this immunological function we sought to investigate the regulation, and in particular the downregula-tion of IDO by the immune system. We describe here the effect of cytokines on IDO activation and in particular the inhibitory function of IL-10, TGFβ and IL-4.

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Indoleamine 2,3-dioxygenase

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Authors and Affiliations

Institute for Medical Microbiology and Virology, Heinrich-Heine University, Universitätsstraβe 1, 40225, Düsseldorf, Germany
Colin R. MacKenzie, Raquel Guadarrama González, Eva Kniep, Simone Roch & Walter Däubener

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Colin R. MacKenzie
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Raquel Guadarrama González
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Eva Kniep
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Simone Roch
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Walter Däubener
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Department of Psychiatry, University of Göttingen, Göttingen, Germany
Gerald Huether
Department of Clinical Chemistry, University of Heidelberg, Heidelberg, Germany
Walter Kochen
Department of Food Chemistry, University of Hamburg, Hamburg, Germany
Thomas J. Simat
Department of Food Chemistry, University of Hamburg, Hamburg, Germany
Hans Steinhart

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MacKenzie, C.R., González, R.G., Kniep, E., Roch, S., Däubener, W. (1999). Cytokine Mediated Regulation of Interferon-Gamma-Induced Ido Activation. In: Huether, G., Kochen, W., Simat, T.J., Steinhart, H. (eds) Tryptophan, Serotonin, and Melatonin. Advances in Experimental Medicine and Biology, vol 467. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-4709-9_66

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DOI: https://doi.org/10.1007/978-1-4615-4709-9_66
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-7133-5
Online ISBN: 978-1-4615-4709-9
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