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Cytokine Blockade in Rheumatoid Arthritis

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation VIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 490))

  • 124 Accesses

  • 54 Citations

Abstract

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As we enter the 2000’s it is clear that cytokine blockade is an effective therapeutic strategy for rheumatoid arthritis. In this brief review, we will review the rationale for anti TNFa therapy, the current status of therapy and focus on the regulation of TNFa production in rheumatoid synovium. New approaches to studying TNF regulation in RA and of elucidating the controversial role of T cells in this complex disease will be described.

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Authors and Affiliations

  1. Kennedy Institute of Rheumatology, 1 Aspenlea Road, Hammersmith, London, W6 8LH, UK

    Marc Feldmann, Ravinder N. Maini, Jan Bondeson, Peter Taylor, Brian M. J. Foxwell & Fionula M. Brennan

Authors
  1. Marc Feldmann
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  2. Ravinder N. Maini
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  3. Jan Bondeson
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  4. Peter Taylor
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  5. Brian M. J. Foxwell
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  6. Fionula M. Brennan
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Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

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Feldmann, M., Maini, R.N., Bondeson, J., Taylor, P., Foxwell, B.M.J., Brennan, F.M. (2001). Cytokine Blockade in Rheumatoid Arthritis. In: Gupta, S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VIII. Advances in Experimental Medicine and Biology, vol 490. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-1243-1_13

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  • DOI: https://doi.org/10.1007/978-1-4615-1243-1_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-5458-1

  • Online ISBN: 978-1-4615-1243-1

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