Fibrotic diseases: from models to therapies

Fibrosis, characterized by excessive connective tissue formation, poses a major challenge in various conditions, including liver cirrhosis, pulmonary fibrosis, and cutaneous scar. Recent advances have illuminated the potential of in-vitro models and 3D tissue engineering to better mimic the fibrotic environment, paving the way for innovative therapies aimed at promoting scarless wound healing and tissue regeneration.

The exploration of molecular mechanism in the context of fibrosis has led to promising breakthroughs, such as the identification of specific stem cell populations that can modulate fibrotic responses and enhance tissue repair. Furthermore, the development of advanced in-vitro models has allowed researchers to study the cellular and molecular mechanisms underlying fibrosis in a controlled environment, facilitating drug screening and the evaluation of therapeutic strategies. As we continue to deepen our understanding of these complex processes, we can anticipate future advances that may include novel cell-based therapies, targeted molecular interventions, and personalized medicine approaches that address the unique fibrotic profiles of individual patients.

We invite researchers to contribute to this Collection by submitting original research and review articles. Topics of interest include but are not limited to:

- Mechanisms of fibrosis

- Stem cell therapy for fibrosis

- In-vitro models of fibrotic diseases

- 3D models in fibrosis research

- Wound healing and fibrosis

- Therapeutic strategies for fibrosis

- Biomarkers of fibrotic diseases

Clinical applications of cell therapy.

All submissions in this collection undergo the journal’s standard peer review process. Similarly, all manuscripts authored by a Guest Editor(s) will be handled by the Editor-in-Chief. As an open access publication, this journal levies an article processing fee (details here). We recognize that many key stakeholders may not have access to such resources and are committed to supporting participation in this issue wherever resources are a barrier. For more information about what support may be available, please visit OA funding and support, or email [email protected] or the Editor-in-Chief.