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T-type Calcium Channels in Basic and Clinical Science

  • Book
  • © 2015

Overview

Editors:
  1. Stephen W. Schaffer

    1. Dept. Pharmacology, University of South Alabama School of Medicine, Mobile, USA

  2. Ming Li

    1. Department of Physiology, Tulane University School of Medicine, New Orleans, USA

  • First comprehensive overview to the topic
  • Introduces new concepts in therapeutical treatment
  • With contributions of international experts

  • 6334 Accesses

  • 3 Citations

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About this book

T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.​

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. General Properties of T-Type Ca2+ Channels

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Physiology and Pathology of Voltage-Gated T-Type Calcium Channels

      • Adriano Senatore, J. David Spafford
      Pages 3-17

    3. Regulation of T-Type Ca2+ Channels by Intercellular and Intracellular Signals

      • Ming Li, Songwei Wu
      Pages 19-35

    4. Pharmacological Profiles of T-Type Calcium Channel Antagonists

      • Norio Hashimoto, Takeshi Kawazu
      Pages 37-48

  3. Role of T-Type Ca2+ Channels in Disease

    1. Front Matter

      Pages 49-49
      Download chapter PDF

    2. Role of T-Type Calcium Channels in Neuroendocrine Differentiation

      • Marine Warnier, Florian Gackière, Morad Roudbaraki, Pascal Mariot
      Pages 51-71

    3. Regulation of Cardiac Hypertrophy by T-Type Ca2+ Channel

      • Stephen W. Schaffer, Chian Ju Jong
      Pages 73-84

    4. Role of T-Type Ca2+ Channels in the Development of Arrhythmias and Ischemia–Reperfusion Injury

      • Stephen W. Schaffer
      Pages 85-95

    5. Link Between Absence Seizures and T-Type Calcium Channels

      • Yucai Chen, W. Davis Parker
      Pages 97-111

    6. Regulation of T-Type Ca2+ Channels in Cancer Cell Cycle

      • Jonathan E. Pottle, Lloyd S. Gray
      Pages 113-128

    7. T-Type Calcium Channels and Management of Pain

      • Brian M. Keyser
      Pages 129-136

    8. Role of T-Type Ca2+ Channels in Basal Insulin Release

      • Ming Li
      Pages 137-150

  4. Back Matter

    Pages 151-154
    Download chapter PDF
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Editors and Affiliations

  • Dept. Pharmacology, University of South Alabama School of Medicine, Mobile, USA

    Stephen W. Schaffer

  • Department of Physiology, Tulane University School of Medicine, New Orleans, USA

    Ming Li

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Bibliographic Information

  • Book Title: T-type Calcium Channels in Basic and Clinical Science

  • Editors: Stephen W. Schaffer, Ming Li

  • DOI: https://doi.org/10.1007/978-3-7091-1413-1

  • Publisher: Springer Vienna

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer-Verlag Wien 2015

  • Hardcover ISBN: 978-3-7091-1412-4Published: 12 December 2014

  • Softcover ISBN: 978-3-7091-1954-9Published: 23 August 2016

  • eBook ISBN: 978-3-7091-1413-1Published: 26 November 2014

  • Edition Number: 1

  • Number of Pages: X, 154

  • Number of Illustrations: 11 b/w illustrations, 6 illustrations in colour

  • Topics: Molecular Medicine, Cell Biology, Human Physiology

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