Fig. 6

Overall survival in the entire patient cohort and in patients with hepatic encephalopathy grade ≥ 2. Overall survival (OS) for 28-days following fulfillment of acute liver failure (ALF) criteria is shown as Kaplan-Meier graphs for all patients (A) and for patients additionally stratified by therapeutic strategy (standard of care (SOC) vs. adjunctive therapeutic plasma exchange (PEX) (B) in the entire cohort. Further, OS is shown for the subgroup of patients with maximal hepatic encephalopathy (HE) grade ≥ 2 (C) and for these patients additionally stratified by therapeutic strategy (SOC) vs. PEX) (D). p-values < 0.05 were considered significant