";
ss += "
2024
Impact Factor
6.9
Impact Factor
6.9
Factors regulating mitochondrial function in AD. In AD, neuronal injury, inflammation and aging may impair mitochondrial function by inducing fission, increasing ∆ψm and ROS production leading to decreased ATP production. Mitochondrial function may be improved by enhancing mitochondrial biogenesis through caloric restriction and exercise. Damaged and dysfunctional mitochondria can be selectively eliminated by mitophagy.","thumbnailUrl":"null/thumbnail/ad-7-2-201-g1.png"}],"article":{"juan":"7","endNoteUrl_en":"http://www.aginganddisease.org/new/EN/article/getTxtFile.do?fileType=EndNote&id=147504","bibtexUrl_cn":"http://www.aginganddisease.org/new/CN/article/getTxtFile.do?fileType=BibTeX&id=147504","articleType":"A","abstractUrl_en":"http://www.aginganddisease.org/new/EN/10.14336/AD.2015.1007","qi":"2","id":147504,"nian":2016,"bianHao":"2152-5250-2016-2-201","juanUrl_en":"http://www.aginganddisease.org/new/EN/Y2016","shouCiFaBuRiQi":"2016-04-01","qiShiYe":"201","accepted":"2015-10-07","received":"2015-09-02","qiUrl_cn":"http://www.aginganddisease.org/new/CN/Y2016/V7/I2","pdfSize":"901KB","risUrl_cn":"http://www.aginganddisease.org/new/CN/article/getTxtFile.do?fileType=Ris&id=147504","doi":"10.14336/AD.2015.1007","jieShuYe":"214","keywordList_en":["Alzheimer’s disease","mitochondria","mitophagy","oxidative stress","neuroinflammation","mitochondrial biogenesis","neuroinflammation"],"endNoteUrl_cn":"http://www.aginganddisease.org/new/CN/article/getTxtFile.do?fileType=EndNote&id=147504","zhaiyao_en":"
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by the progressive loss of cholinergic neurons, leading to the onset of severe behavioral, motor and cognitive impairments. It is a pressing public health problem with no effective treatment. Existing therapies only provide symptomatic relief without being able to prevent, stop or reverse the pathologic process. While the molecular basis underlying this multifactorial neurodegenerative disorder remains a significant challenge, mitochondrial dysfunction appears to be a critical factor in the pathogenesis of this disease. It is therefore important to target mitochondrial dysfunction in the prodromal phase of AD to slow or prevent the neurodegenerative process and restore neuronal function. In this review, we discuss mechanisms of action and translational potential of current mitochondrial and bioenergetic therapeutics for AD including: mitochondrial enhancers to potentiate energy production; antioxidants to scavenge reactive oxygen species and reduce oxidative damage; glucose metabolism and substrate supply; and candidates that target apoptotic and mitophagy pathways to remove damaged mitochondria. While mitochondrial therapeutic strategies have shown promise at the preclinical stage, there has been little progress in clinical trials thus far.","bibtexUrl_en":"http://www.aginganddisease.org/new/EN/article/getTxtFile.do?fileType=BibTeX&id=147504","abstractUrl_cn":"http://www.aginganddisease.org/new/CN/10.14336/AD.2015.1007","juanUrl_cn":"http://www.aginganddisease.org/new/CN/Y2016","lanMu_en":"Review Article","qiUrl_en":"http://www.aginganddisease.org/new/EN/Y2016/V7/I2","revRequest":"2015-10-06","risUrl_en":"http://www.aginganddisease.org/new/EN/article/getTxtFile.do?fileType=Ris&id=147504","title_en":"Mitochondrial Dysfunction in Alzheimer’s Disease and the Rationale for Bioenergetics Based Therapies","hasPdf":"true"},"authorList_en":[{"deceased":false,"xref":"1","name_cn":"Isaac G. Onyango","xref_en":"1, *","name_en":"Isaac G. Onyango"},{"deceased":false,"xref":"1","name_cn":"Jameel Dennis","xref_en":"1","name_en":"Jameel Dennis"},{"deceased":false,"xref":"1","name_cn":"Shaharyah M. Khan","xref_en":"1","name_en":"Shaharyah M. Khan"}]}; if(window.metaData && (!window.metaData.authorNotesCommon_cn && !window.metaData.authorNotesCorresp_cn && window.metaData.authorNotes_cn)){ window.metaData.authorNotesCommon_cn = window.metaData.authorNotes_cn; } if(window.metaData && (!window.metaData.authorNotesCommon_en && !window.metaData.authorNotesCorresp_en && window.metaData.authorNotes_en)){ window.metaData.authorNotesCommon_en = window.metaData.authorNotes_en; } var _nlmdtdXml = $("#article_nlmdtdXml").val(); var magDir = _nlmdtdXml.replace(/\/[^\/]+$/,''); window.metaData.magDir = magDir; new mag_vue({ el: '#metaVue', data:window.metaData, loading:true, doTextFun:function(text){ return doDataJsonText(text); }, doAfterFun:function(selector,jsonData){doMagVueAfter(selector,jsonData);} }); var pars = {attachType:'PDF',id:$("#articleId").val(),json:true}; jQuery.post($("#mag-common-contextPath").val()+"/EN/article/showArticleFile.do?" + new Date().getTime(), pars, function(data){ var json=null; if(data.match(/^\[json\].*/g)){ json=eval("("+data.replace(/^\[json\]/g,"")+")"); } if(json && json.status == 1){ //有权限 }else{ //无权限 $("#no-access-div").show(); } }); mag_ajax({ url:mag_currentQikanUrl() + '/EN/article/getRichHtmlJson.do', data:{articleId:$("#articleId").val(),token:'981cdbdc7c1e494ba723d6f447b68a83',referer:document.referrer}, dataType:"json", async:"false", success:function(json){ if(json.richHtmlJson && json.richHtmlJson.article){ if(json.trans){ var _nlmdtdXmlCN = $("#article_nlmdtdXmlCN").val(); var magDirCN = _nlmdtdXmlCN.replace(/\/[^\/]+$/,''); json.richHtmlJson.magDir=magDirCN; }else{ json.richHtmlJson.magDir=magDir; } new mag_vue({ el: '#bodyVue', data:json.richHtmlJson, doTextFun:function(text){ return doDataJsonText(text); }, doAfterFun:function(selector,jsonData){doMagVueAfter(selector,jsonData);} }); } } }); //去掉正文中的中文文字“多媒体文件” $("div.mag_body_media_file b").remove(); //altmetric if($.trim($("#article_doi").val())!=''){ $.ajax({ url:'https://api.altmetric.com/v1/doi/'+$.trim($("#article_doi").val())+'?callback=altmetric_callback', //url:'https://api.altmetric.com/v1/doi/10.1007/s13238-016-0264-7?callback=altmetric_callback', dataType:'jsonp' }); } mag_rich_menu(jQuery); $(function(){ $('#autoMenu').autoMenu(); }) $("#autoMenu").niceScroll({ cursorcolor: "#ccc", //滚动条的颜色 cursoropacitymax: 0, //滚动条的透明度，从0-1 touchbehavior: false, //使光标拖动滚动像在台式电脑触摸设备 true滚动条拖动不可用 cursorwidth: "6px", //滚动条的宽度 单位默认px cursorborder: "0", // 游标边框css定义 cursorborderradius: "3px", //滚动条两头的圆角 autohidemode: true, //是否隐藏滚动条 true的时候默认不显示滚动条，当鼠标经过的时候显示滚动条 zindex: "auto", //给滚动条设置z-index值 railvalign:'defaul', railpadding: { top: 0, right: -6, left: 0, bottom: 0 }, //滚动条的位置 }); window.autoMenuFlag=true; $("#relatedArticles").niceScroll({ cursorcolor: "#ccc", //滚动条的颜色 cursoropacitymax: 0, //滚动条的透明度，从0-1 touchbehavior: false, //使光标拖动滚动像在台式电脑触摸设备 true滚动条拖动不可用 cursorwidth: "6px", //滚动条的宽度 单位默认px cursorborder: "0", // 游标边框css定义 cursorborderradius: "3px", //滚动条两头的圆角 autohidemode: true, //是否隐藏滚动条 true的时候默认不显示滚动条，当鼠标经过的时候显示滚动条 zindex: "auto", //给滚动条设置z-index值 railvalign:'defaul', railpadding: { top: 0, right: -6, left: 0, bottom: 0 }, //滚动条的位置 }); //公式序号 居右 jQuery(".mag-xml-disp-formula").each(function() { var _this = jQuery(this); var _label= _this.children("label"); if(typeof(_label.html())!="undefined"){ _this.children("label").remove(); _this.wrap("
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