ÐÏà¡±á > þÿ T V þÿÿÿ S ÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿÿì¥Á ` ð¿ % bjbjËsËs *F © © ÿÿ ÿÿ ÿÿ ¤ 6 6 6 6 6 6 6 J / / / / / t J : " š/ š/ š/ š/ š/ š/ š/ š/ †9 ˆ9 ˆ9 ˆ9 ˆ9 ˆ9 ˆ9 $ ); h ‘= ^ ¬9 6 š/ š/ š/ š/ š/ ¬9 6 6 š/ š/ Á9 f9 f9 f9 š/ Ê 6 š/ 6 š/ †9 f9 š/ †9 f9 f9 6 6 f9 š/ Ž/ uÞ\Æ / d3 Ú f9 †9 ×9 0 : f9 ï= >9 ( ï= f9 ï= 6 f9 š/ š/ f9 š/ š/ š/ š/ š/ ¬9 ¬9 f9 š/ š/ š/ : š/ š/ š/ š/ J J J Ä* / J J J / J J J 6 6 6 6 6 6 ÿÿÿÿ Table S1. List of genes that are differentially expressed in both regenerating fin and heart Upregulated genes Functional category Gene symbol Gene title Accession No. Apoptosis related birc5a survivin1 AY057057.1 Apoptosis/phagocytosis elmo1 engulfment and cell BI877952 motility 1 Cell cycle mps1 monopolar spindle 1 NM_175042.2 cdc20 cell division cycle 20 AW116246 homolog cdca8l cell division cycle BI704246 associated 8-like plk1 polo-like kinase 1 AW116681 cdc2 cell division cycle 2 AF268044.1 ccna2 cyclin A2 NM_152949.1 zgc:112133 similar to mitotic spindle BI866657 assembly checkpoint protein MAD2A (MAD2-like 1) Cell matrix and cell timp2l tissue inhibitor of AW420494 adhesion matrix matelloproteinase 2 mmp14a matrix matelloproteinase 14 AA606011 alpha BI475931 timpl tissue inhibitor of metallo- BQ131818 proteinase 2, like mmp14b matrix metalloproteinase 14, BE200676 beta LOC565402 similar to collagen type XI, AL724939 alpha 1 col1a1 collagen type 1, alpha 1 NM_199214 BE201886 col1a2 collagen type 1, alpha 2 AI331605 BI707807 wu:fa99f12 collagen alpha I (XII) BQ449552 nid2 nidogen 2 AI601403 fn1 fibronectin 1 NM_131520.1 AF081127.1 fn1b fibronectin 1b BI707688 dcn decorin BC044206 tgfbi TGF beta-induced AB086407 bgl3 biglycan-like protein 3 BQ092573 Coagulation LOC561287 embryonic BQ285074 transglutaminase Electron transport zgc:92903 thioredoxin BI864002 pdia4 protein disulfide isomerase BC045862.1 A4 precursor Inflammation tsg-6 TNF-a induced protein 6 BQ615550 BQ092008 tnc tenascin C X89203.1 Ion binding fth1 ferritin heavy chain AW232676 Ligand/ Secreted LOC570224 C type natriuretic BQ092110 Peptide 4 mdka midkine related factor a CD014404 igf2 insulin-like growth factor 2 AF250289 precursor clu clusterin AW077466 LOC570373/ similar to apolipoprotein C-I BM186239 LOC570638 zgc:56225/metrnl meteorin, glial cell BC046006.1 differentiation regulator like Metabolism AW510294 AW510294 AW510294 ugdh UDP-glucose dehydrogenase BM096064 zgc:110691 glucosamine-6-phosphate BQ262910 isomerase zgc:110343 peroxiredoxin 1 CD594679 ndpkz3 nucleoside diphosphate NM_130928.1 kinase-Z3 cpn1 carboxypeptidase N, BI704530 polypeptide 1 zgc:92215 histidyl-tRNA synthetase AI957786 zgc:77447 protein-lysine 6-oxidase BG302899 aldh1a2 aldehyde dehydrogenase 1 NM_131850.1 family, membrane A2 dut dUTP pyrophosphatase BQ617623 wu:fc12b04 protein-glutamine gamma- AF242545.1 glutamyltransferase Nuclear import kpna2 karyopherin alpha 2 BI878593 zgc:101013 nuclear transport factor 2 BM402118 Protein folding calrl calreticulin like BC046906.1 calr calreticulin NM_131047.1 hspa5 heat shock 70 KDa protein 5 BC052971.1 fkbp10 FK506 binding protein 10 BC045938.1 LOC570980 similar to FK506 binding AI974136 protein 14 zgc:101826 similar to FK506 binding BI979906 protein 2 LOC558042 peptidylprolyl isomerase- AL717190 ike 1 Protein transport kdelr3 KDEL ER protein retention CD605145 Retention receptor 3 rrbp1 ribosome binding protein 1 AW342746 homolog Selenium binding sepm selenoprotein M NM_178286.2 Signaling marcks myristoylated alanine rich BQ078442 protein kinase C substrate LOC562094 similar to transmembrane AW128322 phosphatase with tensin homology Structural LOC573216 tubulin alpha 2, isoform 2 BG306212 tubb5 tubulin beta 5 AF528096.1 Structural/transcriptional csrp1 cysteine and glycine-rich BM534006 Regulation protein 1 Transcription phf5a PHD finger protein 5A NM_173266.1 atf3 activating transcription BC045371.1 factor 3 lmo4l LIM domain only 4, like AF398515.1 junb jun B proto-oncogene BC053234.1 Transporter slc39a7 solute carrier family 39 AI437101 BQ480733 zgc:56419 similar to SERP1 BC049018.1 Unknown Dr.Affx.2.1.S1_at Dr.Affx.2.1.S1_at AY380819 id:ibd1087 id:ibd1087 BG985449 wu:fi13a08 wu:fi13a08 AW116248 LOC558965 similar to ubquitin-like BQ075086 protein 1 wu:fd57e01 wu:fd57e01 AL720987 zgc:77059 zgc:77059 AW421190 sb:cb185 similar to cystatin B BM184265 LOC562013 similar to MGC78892 protein BQ284889 im:7151414 im:7151414 BM342191 zgc:63590 zgc:63590 BM181793 wu:fj86h11 similar to ubiquitin- BM531174 conjugating enzyme E2T LOC562022 / similar to Olfactomedin-like BQ074534 LOC563065 / protein 3 LOC566649 LOC561086 similar to CG14434-PA CD593876 zgc:103578 zgc:103578 AW281699 sb:cb377 sb:cb377 BE693156 id:ibd5063 id:ibd5063 BG985448 wu:fk30a05 wu:fk30a05 AW566977 BC046015.1 BC046015.1 BC046015.1 LOC562399 similar to ectonucleotide BE605993 Pyrophosphatase zgc:109978 zgc:109978 AL730317 wu:fc59b06 wu:fc59b06 AI878469 BM532441 BM532441 BM532441 zgc:77153 zgc:77153 BI877516 LOC562094 similar to transmembrane AW128322 phosphatase with tensin homology AW420565 AW420565 AW420565 zgc:77327 zgc:77327 zgc:77327 wu:fi13a08 wu:fi13a08 AW116248 wu:fc60b09 wu:fc60b09 AL715802 wu:fb09f08 wu:fb09f08 AI397304 CB362946 CB362946 CB362946 wu:fc87g11 wu:fc87g11 AI943264 AL913978 AL913978 AL913978 wu:fl17h04 wu:fl17h04 BE558041 wu:fl03b09 wu:fl03b09 BE201936 wu:fa99c11 wu:fa99c11 AI942877 id:ibd5063 id:ibd5063 BG985448 AI545309 AI545309 AI545309 wu:fj65f09 wu:fj65f09 BQ092092 LOC553997 progranulin-1progranulin-2 AY289607.1 antisense transcript zgc:86646 zgc:86646 AI793417 zgc:91863 zgc:91863 BI428259 zgc:86839 zgc:86839 AI959618 zgc:100902 zgc:100902 AI943251 zgc:103420 zgc:103420 zgc:103420 Downregulated genes Functional category Gene symbol Gene title Accession No. Calcium binding anxa4 annexin 4 AW117084 Metabolism arg2 arginase type II BG891983 Ligand/Secreted inhbb inhibin beta B NM_131068.1 Signaling zgc:55498 similar to mitogen-activated BC044411.1 protein kinase 4 (ERK4) Transporter (plasma) rbp4 retinol binding protein 4 AW232202 Transcription reverbb1 rev erb beta 1 BF937474 klf12 Kruppel-like factor 12 NM_131859.1 BI878775 similar to basic transcription BI878775 element binding protein 1 Unknown wu:fa94b01 wu:fa94b01 AI332232 zgc:110777 zgc:110777 BG305771 wu:fc63h12 wu:fc63h12 AI878665 wu:fb81c07 wu:fb81c07 CD283215 LOC572832 putative nucleic acid binding BI864314 protein Upregulated in heart but downregulated in fin Metabolism zgc:65956 zgc:65956 AI883922 Immune response zgc:92049 MHC clasII integral NM_131695.1 membrane protein alpha chain 3 Unknown BG884598 BG884598 BG884598 LOC566658 LOC566658 BE201834 zgc:63831/ zgc:63831/LOC554451 AI332262 LOC554451 wu:fc33f12 wu:fc33f12 AI723186 AW279710 AW279710 AW279710 CD283908 CD283908 CD283908 Downregulated in heart but upregulated in fin Protein folding hsp90a heat shock protein-90 alpha BM103343 Structural kif11 kinesin family member 11 NM_173261.1 Transcription cited3 similar to Cbp/p300- BG305277 interacting transactivator, cited3 B O r ´ µ Æ é ÿ 5 ? ¶ Ë ô ü Ÿ ª ä ö ] i Ï Ú y ƒ Ð Þ < K ¼ Í Q a ˆ ‘ : D ¤ ¾ ë õ Ò Ý G N € ^ q Ÿ ® Ï Ù ÿ 6 ? ˜ ¬ Ø å ! ! ! —! £" " Ó" â" 2# 9# E$ U$ †$ ‘$ ¾$ Ì$ % üøüøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóøëøóøóøóøóøóøóøóøóøóøóøóøóøóøóøóø h¥] OJ QJ h¥] 5h¥] hƒ9 R ] ^ _ q r ´ µ è é ' 4 5 j o ˜ £ ¤ Ë à á / 0 P Q ý ý ý û ý ý ý ý ý ý ñ ý ý ý ç ç ç ç ç ç ç ç ç ç ç ç „p„Ð^„p`„Ð „à„Ð^„à`„Ð % ý 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