Article PDF
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Abott, DW, Freeman, LF & Holt, JT (1998). Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cell lines. JNCI 90: 978–985.
Anderson, SF, Schlegel, BP, Nakajima, T, Wolpin, ES & Parvin, JD (1998). BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet 19: 254–257.
Andres, JL, Fan, S, Turkel, GJ, Wang, JA, Twu, NF, Yuan, RQ, Lamszus, K, Goldberg, ID & Rosen, EM (1998). Regulation of BRCA1 and BRCA2 expression in human breast cancer cells by DNA-damaging agents. Oncogene 16: 2229–2241.
Blackshear, P, Goldsworthy, SM, Foley, JF, McAllister, KA, Bennet, ML, Collins, K, Bunch, DO, Brown, P, Wiseman, RW & Davis, B (1998). Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene 16: 61–68.
Bork, P, Hofman, K, Bucher, P, Neuwald, AF, Altschul, SF & Koonin, EV (1997). A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J 11: 68–76.
Callebaut, I & Mornon, JP (1997). From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett 400: 25–30.
Chapman, MS & Verma, IM (1996). Transcriptional activation by BRCA1. Nature 382: 678–679.
Chen, J, Silver, DP, Walpita, D, Cantor, SB, Gazdar, AF, Tomlinson, G, Couch, F, Weber, BL, Ashley, T, Livingston, DM & Scully, R (1998). Stable interaction between the products of the BRCA1 and BRCA2 tumour suppressor genes in mitotic and meiotic cells. Mol Cell 2: 317–328.
Chen, P, Chen, C, Chen, Y, Xiao, J, Sharp, ZD & Lee, W (1998). The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc Natl Acad Sci USA 95: 5287–5292.
Collins, N, McManus, R, Wooster, R, Mangion, J, Seal, S & Lakhani, SR et al (1995). Consistent loss of the wild type allele in breast cancers from a family linked to the BRCA2 gene on chromosome 13q12–13. Oncogene 10: 1673–1675.
Devary, Y, Rowsette, C, DiDonato, JA & Karin, M (1993). NF-kappa B activation by ultraviolet light not dependent on nuclear signal. Science 261: 1442–45.
Fuks, F, Milner, J & Kouzarides, T (1998). BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene 17: 2531–2534.
Gowen, LC, Johnson, BL, Latour, AM, Sulik, KK & Koller, BH (1996). Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet 12: 191–194.
Gudas, JM, Li, T, Ngiyen, H, Jensen, D, Rauscher, FJ & Cowan, KH (1996). Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ 7: 717–723.
Harkin, PD, Bean, JM, Miklos, D, Song, Y, Truong, VB & Englert, C et al (1999). Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97: 575–586.
Humphrey, JS, Salim, A, Erdos, MR, Collins, FS, Brody, LC & Klausner, RD (1997a). Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing. Proc Natl Acad Sci USA 94: 5820–5825.
Jensen, D, Proctor, M, Marquis, ST, Gardner, HP, Ha, SI, Chodosh, LA, Ishov, AM & Tommerup, N et al (1998). BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1 mediated cell growth in suspension. Oncogene 16: 1097–1112.
Ludwig, T, Chapman, DL, Papaioanou, VE & Efstratiadis, A (1997). Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 11: 1226–1241.
Marcus, JN, Watson, P, Page, DL, Narod, SL, Lenoir, G, Tonin, P & Linder-Stephenson, L (1996). Hereditary breast cancer: pathobiology, prognosis, and BRCA1 and BRCA2 linkage. Cancer 77: 697–709.
Marks, JR, Huper, G, Vaughn, JP, Davis, PL, Norris, J, McDonell, DP, Wiseman, RW, Futreal, PA & Ingelhart, JD (1997). BRCA1 expression is not directly responsive to estrogen. Oncogene 14: 115–121.
Marmorstein, L, Ouchi, T & Aaronson, S (1998). The BRCA2 gene product functionally interacts with p53 and RAD51. Proc Natl Acad Sci USA 95: 13869–13874.
Mazoyer, S, Puget, N, Perrin-Vidoz, L, Lynch, HT, Serova-Sinilnikova, OM & Lenoir, GM (1998). A BRCA1 nonsense mutation causes exon skipping. Am J Hum Genet 62: 713–715.
Miki, Y, Swensen, J, Shattuck-Eidens, D, Futreal, A & Harshman, K et al (1994). A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66–71.
Milner, J, Ponder, BAJ, Hughes-Davies, L, Seltman, M & Kouzarides, T (1997). Transcriptional activation functions of Brca2. Nature 386: 772–773.
Monteiro, ANA, August, A & Hanafusa, H (1996). Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc Natl Acad Sci USA 93: 13595–13599.
Nelson, WG & Kastan, MB (1994). DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 14: 1815–1823.
Neuhausen, SL & Marshall, CJ (1994). Loss of heterozygosity in familial tumours from three BRCA1 linked kindreds. Cancer Res 54: 6069–6072.
Patel, K, Yu, VPC, Lee, H, Corcoran, A, Thistlethwaite, FC, Evans, MJ, Colledge, WH, Friedman, L, Ponder, BA & Venkitaraman, AR (1998). Involvement of Brca2 in DNA repair. Molecular Cell 1: 347–357.
Rajan, JV, Wang, M, Marquis, ST & Chodos, LA (1996). Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci USA 93: 13078–13083.
Scully, R, Anderson, SF, Chao, DM, Wei, W, Ye, L, Young, RA, Livingston, DM & Parvin, JD (1997a). BRCA1 is a component of the RNA Polymerase II holoenzyme. Proc Natl Acad Sci USA 94: 5605–5610.
Scully, R, Chen, J, Plug, A, Xiao, Y, Weawer, D, Feunteun, J, Ashley, T & Livingston, DM (1997b). Association of BRCA1 and RAD51 in mitotic and meiotic cells. Cell 88: 265–275.
Scully, R, Chen, J, Ochst, RL, Keegan, K, Hoekstra, M, Feunteun, J & Livingston, DM (1997c). Dynamic changes of BRCA1 subnuclear localisation and phosphorylation state are initiated by DNA damage. Cell 90: 425–435.
Sharan, SK, Morimatsu, M, Albreicht, U, Lim, D-S, Regel, E, Dinh, C, Sands, A, Hasty, P & Bradley, A (1997). Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386: 804–810.
Siddique, H, Zou, J, Rao, VN & Reddy, SP (1998). The BRCA2 is a histone acetyltransferase. Oncogene 16: 2283–2285.
Somasundaram, K, Zhang, H, Zeng, Y, Houvras, Y, Peng, Y, Zhang, H, Sheng Wu, G, Licht, D, Weber, B & El-Diery, WS (1997). Arrest of the cell cycle by the tumour-supressor BRCA1 requires the CDK-inhibitor p21. Nature 389: 187–190.
Suzuki, A, de la Pompa, JL, Hakem, R, Elia, A, Yoshida, R, Mo, R, Nishina, H, Chuang, T, Wakeham, A & Itier, A et al (1997). Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev 11: 1242–1252.
Thakur, S, Zhang, H, Peng, Y, Le, H, Carroll, B, Ward, T, Yao, J, Farid, LM, Couch, FJ, Wilson, RB & Weber, BL (1997). Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol Cell Biol 17: 444–452.
Vaughn, JP, Davis, PL, Jarboe, MD, Huper, G & Evans, AC et al (1996). BRCA1 expression is induced before DNA synthesis in both normal and tumor derived breast cells. Cell Growth Differ 7: 711–715.
Wang, Q, Zhang, H, Kajino, K & Greene, M (1998). BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 17: 1939–1948.
Wong, AKC, Pero, R, Ormonde, PA, Tavtigian, SV & Bartel, PL (1997). RAD51 interacts with the evolutionary conserved BRC motifs in the human breast cancer susceptibility gene Brca2. J Biol Chem 272: 31941–31944.
Wooster, R, Bignell, G, Lancaster, J, Swift, S, Seal, S, Mangion, J, Collins, N & Gregory, S et al (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature 378: 789–791.
Zhang, H, Somasundaram, K, Peng, Y, Tian, H, Zhang, H, Bi, D, Weber, B & El-Diery, WS (1998). BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16: 1713–1721.
Zheng, H, Tombline, G & Weber, B (1998). BRCA1, BRCA2 and DNA damage Response: collision or collusion?. Cell 92: 433–463.
Author information
Authors and Affiliations
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Kote-Jarai, Z., Eeles, R. BRCA1, BRCA2 and their possible function in DNA damage response. Br J Cancer 81, 1099–1102 (1999). https://doi.org/10.1038/sj.bjc.6690814
Received:
Accepted:
Published:
Issue date:
DOI: https://doi.org/10.1038/sj.bjc.6690814
This article is cited by
-
BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients
British Journal of Cancer (2011)
-
Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers
British Journal of Cancer (2006)
-
The Notch pathway in ovarian carcinomas and adenomas
British Journal of Cancer (2005)
-
Future possibilities in the prevention of breast cancer: Intervention strategies in BRCA1 and BRCA2 mutation carriers
Breast Cancer Research (2000)
