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Cell death

The many paths ascending to ferroptosis

Nature Chemical Biology volume 21, pages 18–19 (2025)Cite this article

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In 2012, a study revealed a unique form of cell death, termed ferroptosis, that is dependent on iron and unregulated lipid peroxidation. We revisit how this paper changed the trajectory of ferroptosis research from its origins to its current state.

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Fig. 1: The many paths ascending to ferroptosis.

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Authors and Affiliations

  1. Institute of Metabolism and Cell Death, Helmholtz Munich, Neuherberg, Germany

    Marcus Conrad & Adam Wahida

  2. Translational Redox Biology, TUM Natural School of Sciences, Technical University of Munich (TUM), Munich, Germany

    Marcus Conrad

Authors
  1. Marcus Conrad
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  2. Adam Wahida
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Correspondence to Marcus Conrad.

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Competing interests

M.C. is a co-founder and shareholder of ROSCUE Therapeutics GmbH and holds patents for some of the compounds described herein.

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Conrad, M., Wahida, A. The many paths ascending to ferroptosis. Nat Chem Biol 21, 18–19 (2025). https://doi.org/10.1038/s41589-024-01794-z

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