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Alcoholic hepatitis

Potential role of cytokine CCL20 in alcoholic hepatitis

Nature Reviews Gastroenterology & Hepatology volume 11, page 76 (2014)Cite this article

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The cytokine CCL20 might have a role in the pathogenesis of alcoholic hepatitis (AH), and has potential as a new therapeutic target in this devastating disease, according to a new study.

AH is the most severe form of alcoholic liver disease (ALD), and is associated with high rates of mortality. Poor understanding of the pathophysiology of this condition, lack of appropriate experimental models and limited interest from pharmaceutical companies have combined to mean that very few drugs have been developed for ALD and AH.

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References

  1. Affó, S. et al. CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis. Gut 10.1136/gutjnl-2013-306098

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  1. Isobel Leake
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Leake, I. Potential role of cytokine CCL20 in alcoholic hepatitis. Nat Rev Gastroenterol Hepatol 11, 76 (2014). https://doi.org/10.1038/nrgastro.2014.9

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