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Common factors among three types of cells aged in mice

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The greatest risk factor for the formation of numerous significant chronic disorders is aging. Understanding the core molecular underpinnings of aging can help to slow down the inevitable process. Systematic study of gene expression or DNA methylation data is possible at the transcriptomics and epigenetics levels. DNA methylation and gene expression are both affected by aging. Gene expression is an important element in the aging of Homo sapiens. In this work, we evaluated the expression of differentially expressed genes (DEGs), proteins, and transcription factors (TFs) in three different types of cells in mice: antibody-secreting cells, cardiac mesenchymal stromal cells, and skeletal muscle cells. The goal of this article is to uncover a common cause during aging among these cells in order to increase understanding about establishing complete techniques for preventing aging and improving people's quality of life. We conducted a comprehensive network-based investigation to establish which genes and proteins are shared by the three different types of aged cells. Our findings clearly indicated that aging induces gene dysregulation in immune, pharmacological, and apoptotic pathways. Furthermore, our research developed a list of hub genes with differential expression in aging responses that should be investigated further to discover viable anti-aging treatments.

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Data availability

All data used in this study is freely available and can be obtained from NCBI using above-mentioned GSE codes “GSE72224”, “GSE129656” and “GSE125815”.

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Acknowledgements

The author thanks Dr. Rasoul Godini (Monash University, Australia) for his help.

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  1. Department of Biology, School of Sciences, Razi University, Baq-e-Abrisham, 6714967346, Kermanshah, Islamic Republic of Iran

    Mehran Radak, Nakisa Ghamari & Hossein Fallahi

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  2. Nakisa Ghamari
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MR and HF: designed the experiment and analyzed the data. NG: performed the calculations. All authors provided critical feedback and helped shape the research, analysis and manuscript.

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Correspondence to Hossein Fallahi.

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Radak, M., Ghamari, N. & Fallahi, H. Common factors among three types of cells aged in mice. Biogerontology 24, 363–375 (2023). https://doi.org/10.1007/s10522-023-10035-0

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