Rosetta Commons

An Innovative Model for Collaboration.

Advancing biomolecular modeling tools and the diverse community of biomolecular structural modelers and designers.

Upcoming Events

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Rosetta Megathon is on March 2-6, 2026, in  San Juan, Puerto Rico

 

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Summer RosettaCon 2026 is on Aug 3-7, 2026, at the University of Washington in Seattle, WA.

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AI for Protein Design is on November 3-9, 2025, Puerto Varas, Chile.

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Latest News

Designing Proteins That Know When to Let Go

October 23, 2025

In biology, timing is everything. From a neuron firing at the right moment to an immune signal fading at just…

A New Generation of Vaccines: Combining Design and Delivery

October 23, 2025

In the wake of the COVID-19 pandemic, two vaccine technologies stood out – mRNA vaccines like those from Pfizer and…

Rosetta + Cursor: Simplifying Protein Design with AI Assistance 

October 20, 2025

The Rosetta MCP Server project, created by Ariel J. Ben-Sasson, is a powerful tool that will make it easier to…

One-shot design of functional protein binders with BindCraft

September 25, 2025

Authors:  Martin Pacesa, Lennart Nickel, Christian Schellhaas, Joseph Schmidt, Ekaterina Pyatova, Lucas Kissling, Patrick Barendse, Jagrity Choudhury, Srajan Kapoor, Ana…

Rosetta 3.15 Release Highlights

September 23, 2025

The newest version of Rosetta is now available for download: Download Rosetta 3.15. In addition to general improvements, Rosetta 3.15…

Roland Dunbrack Receives ASBMB DeLano Award

September 25, 2025

Rosetta Commons is delighted to celebrate Roland L. Dunbrack, Jr., recipient of the ASBMB DeLano Award for Computational Biosciences. This…

Summer RosettaCon 2025 Recap

September 23, 2025

From August 4 to 8, 2025, the Rosetta community gathered at Suncadia Resort near Seattle, Washington, for Summer RosettaCon 2025.…

Evaluation of De Novo Deep Learning Models on the Protein-Sugar Interactome

September 23, 2025

Paper by: Samuel W. Canner, Lei Lu,  Sho S. Takeshita, Jeffrey J. Gray This study builds the first benchmark for…

AtomWorks & RF3 (in ModelForge) now open-source on GitHub

September 15, 2025

We’re excited to share that two major repositories are live on the RosettaCommons GitHub: AtomWorks and ModelForge.  AtomWorks is a…

RFdiffusion2 is Now Available On GitHub

September 15, 2025

The long awaited inference code for RFdiffusion2 is now public! Developed by the Baker Lab, RFDiffusion2 builds on the capabilities…