Skip to main page content
U.S. flag
See More

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jan 21;100(2):197-207.
doi: 10.1016/s0092-8674(00)81558-5.

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

P Ducy  1 , M Amling, S Takeda, M Priemel, A F Schilling, F T Beil, J Shen, C Vinson, J M Rueger, G Karsenty
Affiliations
Free article

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

P Ducy et al. Cell. .
Free article

Abstract

Gonadal failure induces bone loss while obesity prevents it. This raises the possibility that bone mass, body weight, and gonadal function are regulated by common pathways. To test this hypothesis, we studied leptin-deficient and leptin receptor-deficient mice that are obese and hypogonadic. Both mutant mice have an increased bone formation leading to high bone mass despite hypogonadism and hypercortisolism. This phenotype is dominant, independent of the presence of fat, and specific for the absence of leptin signaling. There is no leptin signaling in osteoblasts but intracerebroventricular infusion of leptin causes bone loss in leptin-deficient and wild-type mice. This study identifies leptin as a potent inhibitor of bone formation acting through the central nervous system and therefore describes the central nature of bone mass control and its disorders.

PubMed Disclaimer

Publication types

MeSH terms