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NVJ2 Nvj2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856207, updated on 30-Jul-2025
Official Symbol
NVJ2
Official Full Name
Nvj2p
Primary source
SGD:S000006295
Locus tag
YPR091C
See related
AllianceGenome:SGD:S000006295; FungiDB:YPR091C; VEuPathDB:YPR091C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lipid binding activity and lipid transporter activity. Involved in ER to Golgi ceramide transport. Located in nucleus-vacuole junction. Is active in endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to human TEX2 (testis expressed 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (716156..718468, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene RNA-binding signal recognition particle subunit SRP54 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An inducible ER-Golgi tether facilitates ceramide transport to alleviate lipotoxicity. Liu LK, et al. J Cell Biol, 2017 Jan 2. PMID 28011845, Free PMC Article
  2. Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria. Kopec KO, et al. Bioinformatics, 2010 Aug 15. PMID 20554689, Free PMC Article
  3. The vacuole controls nucleolar dynamics and micronucleophagy via the NVJ. Tasnin MN, et al. Biochem Biophys Res Commun, 2021 Apr 23. PMID 33706099
  4. A conserved membrane-binding domain targets proteins to organelle contact sites. Toulmay A, et al. J Cell Sci, 2012 Jan 1. PMID 22250200, Free PMC Article
  5. Membrane contact sites regulate vacuolar fission via sphingolipid metabolism. Hanaoka K, et al. Elife, 2024 Mar 27. PMID 38536872, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables lipid transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ER to Golgi ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ER to Golgi ceramide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus-vacuole junction IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Nvj2p
NP_015416.1
  • Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); involved in nonvesicular transfer of ceramides from ER to Golgi during ER stress; may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    716156..718468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184188.1 → NP_015416.1  TPA: Nvj2p

    See identical proteins and their annotated locations for NP_015416.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W491, Q06833
    UniProtKB/TrEMBL
    B3LK58, N1P288
    Conserved Domains (1) summary
    cl17171
    Location:129 → 264
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06833.1

Gene LinkOut

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