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RPS0A 40S ribosomal protein uS2 RPS0A [ Saccharomyces cerevisiae S288C ]

Gene ID: 853128, updated on 12-Aug-2025
Official Symbol
RPS0A
Official Full Name
40S ribosomal protein uS2 RPS0A
Primary source
SGD:S000003446
Locus tag
YGR214W
See related
AllianceGenome:SGD:S000003446; FungiDB:YGR214W; VEuPathDB:YGR214W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NAB1; NAB1A; YST1
Summary
A structural constituent of ribosome. Involved in cytoplasmic translation and ribosome biogenesis. Located in cytoplasmic stress granule. Part of cytosolic small ribosomal subunit. Orthologous to several human genes including RPSA (ribosomal protein SA). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See RPS0A in Genome Data Viewer
Location:
chromosome: VII
Exon count:
2
Sequence:
Chromosome: VII; NC_001139.9 (920575..921788)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase Neighboring gene Rta1p Neighboring gene mitochondrial 37S ribosomal protein mS33 RSM27 Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase

Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Yeast proteins related to the p40/laminin receptor precursor are essential components of the 40 S ribosomal subunit. Demianova M, et al. J Biol Chem, 1996 May 10. PMID 8626693
  2. Yeast proteins related to the p40/laminin receptor precursor are required for 20S ribosomal RNA processing and the maturation of 40S ribosomal subunits. Ford CL, et al. Cancer Res, 1999 Feb 1. PMID 9973221
  3. Identification of pathogenic yeast species by polymerase chain reaction amplification of the RPS0 gene intron fragment. Martínez JM, et al. J Appl Microbiol, 2010 Jun. PMID 19968730
  4. Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. Tabb AL, et al. Genetics, 2001 Mar. PMID 11238398, Free PMC Article
  5. Ribosomal proteins Rps0 and Rps21 of Saccharomyces cerevisiae have overlapping functions in the maturation of the 3' end of 18S rRNA. Tabb-Massey A, et al. Nucleic Acids Res, 2003 Dec 1. PMID 14627813, Free PMC Article

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The interaction between the flexible RPS0A-C-terminal tail and residues 200-400 of the TIF32-N-terminal domain significantly stimulates attachment of eIF3 and its associated eIFs to small ribosomal subunits in vivo.
    Title: Small ribosomal protein RPS0 stimulates translation initiation by mediating 40S-binding of eIF3 via its direct contact with the eIF3a/TIF32 subunit.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal small subunit assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal small subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal subunit export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 90S preribosome HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
40S ribosomal protein uS2 RPS0A
NP_011730.1
  • Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    920575..921788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181343.1 → NP_011730.1  TPA: 40S ribosomal protein uS2 RPS0A

    See identical proteins and their annotated locations for NP_011730.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZUM5, B3LI22, D6VUZ7, P32905
    UniProtKB/TrEMBL
    A0A0L8VPU2, C8Z9A6, G2WEU3, N1P3Z7
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 252
    PTZ00254; 40S ribosomal protein SA; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32905.3

Gene LinkOut

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